Department of Oral & Maxillofacial Surgery, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota-City, Tokyo 145-8515, Japan.
Cytokine. 2013 Nov;64(2):497-502. doi: 10.1016/j.cyto.2013.08.011. Epub 2013 Sep 21.
The objective of this study was to evaluate cytokines in unstimulated whole saliva (UWS) of oral squamous cell carcinoma (OSCC) patients as compared to those with pre- and post-operation for evaluation as markers of OSCC. Sixteen OSCC patients were included in this study. Cytokine concentrations in resting saliva were measured using a Bio-Plex suspension array system. Only interleukin-1 (IL-1) beta showed significantly different cytokine concentration in saliva between pre- and post-operation. IL-1 beta was released from cultured OSCC cells confirmed by ELISA and immunohistochemistry. From this study, IL-1 beta in UWS may be useful for detection of early stage OSCC. More studies are needed to accept the utility of IL-1 beta in UWS for predicting, diagnosis and evaluation of OSCC.
本研究旨在评估口腔鳞状细胞癌（OSCC）患者的非刺激全唾液（UWS）中的细胞因子，并与术前和术后的细胞因子进行比较，将其作为 OSCC 的标志物。本研究纳入了 16 名 OSCC 患者。使用 Bio-Plex 悬浮阵列系统测量静止唾液中的细胞因子浓度。只有白细胞介素-1（IL-1）β在唾液中的浓度在术前和术后之间存在显著差异。ELISA 和免疫组织化学证实，IL-1β可从培养的 OSCC 细胞中释放。本研究表明，UWS 中的 IL-1β可能可用于检测早期 OSCC。需要进一步研究以接受 UWS 中 IL-1β在预测、诊断和评估 OSCC 方面的效用。
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