唾液 microRNA 和细胞因子在口腔鳞状细胞癌的诊断和预后中的作用。
Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma.
机构信息
Biomedical Group (BIO277), Department of Stomatology, School of Dentistry, University of Granada, 18071 Granada, Spain.
Instituto Investigación Biosanitaria, ibs.Granada, 18071 Granada, Spain.
出版信息
Int J Mol Sci. 2021 Nov 11;22(22):12215. doi: 10.3390/ijms222212215.
Abstract
Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.
摘要
口腔鳞状细胞癌（OSCC）是全球最常见的口腔恶性肿瘤。早期诊断对其预后有重大积极影响。人类唾液中含有细胞因子、DNA 和 RNA 分子、循环细胞以及组织和细胞外囊泡的衍生物等，可以作为生物标志物。因此，唾液分析可能为 OSCC 的早期诊断及其预后提供有用信息。本综述的目的是确定唾液生物标志物（细胞因子和 microRNA）在诊断 OSCC 和改善其预后方面的潜在用途。唾液 microRNA 和蛋白质组学数据的组合可以实现明确和早期的诊断。然而，仍需要优化和标准化用于定量 microRNA 的方案。
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