Roi Alexandra, Roi Ciprian Ioan, Negruțiu Meda Lavinia, Riviș Mircea, Sinescu Cosmin, Rusu Laura-Cristina
Department of Oral Pathology, "Victor Babeș" University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, Romania.
Department of Anaesthesiology and Oral Surgery, "Victor Babeș" University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, Romania.
J Clin Med. 2020 Sep 4;9(9):2866. doi: 10.3390/jcm9092866.
Fast, economic, and noninvasive, molecular analysis of saliva has the potential to become a diagnostic tool of reference for several local and systemic diseases, oral cancer included. The diagnosis of Oral Squamous Cell Carcinoma (OSCC) can be performed using high specificity and sensibility biomarkers that can be encountered in the biological fluids. Recent advances in salivary proteomics have underlined the potential use of salivary biomarkers as early diagnosis screening tools for oral neoplasia. In this respect, over 100 salivary molecules have been described and proposed as oral cancer biomarkers, out of which cytokines are among the most promising. Besides being directly involved in inflammation and immune response, the role of salivary cytokines in tumor growth and progression linked them to the incidence of oral malignant lesions. This review summarizes the existing studies based on the use of salivary cytokines as potential oral cancer biomarkers, their involvement in the malignant process based on their type, and ther influence upon prognostic and metastatic rates.
唾液的分子分析快速、经济且无创，有潜力成为包括口腔癌在内的多种局部和全身性疾病的参考诊断工具。口腔鳞状细胞癌（OSCC）的诊断可使用生物体液中具有高特异性和敏感性的生物标志物来进行。唾液蛋白质组学的最新进展突显了唾液生物标志物作为口腔肿瘤早期诊断筛查工具的潜在用途。在这方面，已有超过100种唾液分子被描述并提议作为口腔癌生物标志物，其中细胞因子是最有前景的。除了直接参与炎症和免疫反应外，唾液细胞因子在肿瘤生长和进展中的作用将它们与口腔恶性病变的发生联系起来。本综述总结了基于使用唾液细胞因子作为潜在口腔癌生物标志物的现有研究、它们基于类型在恶性过程中的参与情况以及它们对预后和转移率的影响。
