家族性地中海热和贝切特病患者中特应性的流行情况。

The prevalence of atopy in patients with familial Mediterranean fever and Behçet's disease.

机构信息

Division of Rheumatolgy, Department of Internal Medicine, Medical Faculty, Kocaeli University, Kocaeli, Turkey.

出版信息

Clin Exp Rheumatol. 2013 May-Jun;31(3 Suppl 77):68-70. Epub 2013 Sep 9.

Abstract

OBJECTIVES

The purpose of this study is to investigate the prevalence of atopy in patients with Behçet's disease (BD) and familial Mediterranean fever (FMF).

METHODS

In this study, 42 BD patients, 40 FMF patients and 49 healthy subjects were included. The skin test was applied to the whole group. If one or more allergen response was equal or greater than histamine response, it was accepted as atopy. At the same time, total serum IgE and peripheral blood eosinophil levels were also determined.

RESULTS

The frequency of atopy was found to be 2.4% (1/42 patients) in BD patients and 5% (2/40 patients) in FMF patients and 16.3% (8/49 individuals) in healthy controls. In the BD patients, positivity to skin prick test was significantly lower than the control group (p=0.035). The mean serum total IgE level and eosinophil counts did not differ between the three groups. In 33.3% of BD patients, 39.8% of FMF patients and 20.8% of controls levels of IgE lower than 20 kU/L were found (both groups p<0.05).

CONCLUSIONS

The related conditions with Th-2 cell response such as atopy seem to be low frequency in BD and FMF patients.

摘要

目的

本研究旨在调查白塞病（BD）和家族性地中海热（FMF）患者中特应性的患病率。

方法

本研究纳入了 42 例 BD 患者、40 例 FMF 患者和 49 名健康对照者。对所有受试者均进行皮肤点刺试验。如果一种或多种过敏原的反应与组胺反应相等或更大，则被认为是特应性。同时，还测定了总血清 IgE 和外周血嗜酸性粒细胞水平。

结果

BD 患者中特应性的发生率为 2.4%（42 例患者中有 1 例），FMF 患者中为 5%（40 例患者中有 2 例），健康对照组中为 16.3%（49 例个体中有 8 例）。BD 患者的皮肤点刺试验阳性率显著低于对照组（p=0.035）。三组间血清总 IgE 水平和嗜酸性粒细胞计数无差异。33.3%的 BD 患者、39.8%的 FMF 患者和 20.8%的对照组的 IgE 水平低于 20 kU/L（两组均 p<0.05）。