Eid N S, Shoemaker L R, Samiec T D
Department of Pediatrics, University of Louisville School of Medicine, Kentucky.
J Pediatr Gastroenterol Nutr. 1990 Feb;10(2):265-9.
Much has been learned about vitamin A physiology in the last 50 years, yet few changes have been made in therapy. Unfamiliarity with vitamin A bioavailability and distribution may inadvertently result in toxicity. A literature search demonstrates that hypovitaminosis A has rarely been reported in patients with cystic fibrosis, and may manifest very differently in children of different ages. Furthermore, hypervitaminosis A may present with similar features, and can result from correction of deficiency. We report such a case in a 4.5-month-old infant, newly diagnosed with cystic fibrosis, who suffered first from vitamin A deficiency and then vitamin A toxicity. A brief review of vitamin A physiology, deficiency, and toxicity is presented.
在过去50年里，我们对维生素A生理学有了很多了解，但在治疗方面却几乎没有什么改变。对维生素A生物利用度和分布的不熟悉可能会无意中导致中毒。文献检索表明，囊性纤维化患者中很少有维生素A缺乏症的报道，而且在不同年龄段的儿童中可能表现得非常不同。此外，维生素A过多症可能表现出类似的特征，并且可能由于缺乏症的纠正而导致。我们报告了一例4.5个月大的新诊断为囊性纤维化的婴儿病例，该婴儿先是出现维生素A缺乏，然后出现维生素A中毒。本文简要回顾了维生素A生理学、缺乏症和中毒情况。
