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正常和哮喘血清对尘螨特异性 IgE 依赖性正常嗜酸性粒细胞凋亡的不同抗凋亡作用。

Different anti-apoptotic effects of normal and asthmatic serum on normal eosinophil apoptosis depending on house dust mite-specific IgE.

机构信息

Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Taejon, 301-746, Republic of Korea.

出版信息

Mol Biol Rep. 2013 Oct;40(10):5875-81. doi: 10.1007/s11033-013-2695-z. Epub 2013 Sep 25.

DOI:10.1007/s11033-013-2695-z
PMID:24065529
Abstract

We investigated the effect of asthmatic serum on constitutive eosinophil apoptosis in normal subjects. Eosinophil apoptosis in normal subjects was inhibited by asthmatic serum but not normal serum. In a detailed analysis based on the presence of house dust mite (HDM) IgE, HDM IgE-positive (+) asthmatic serum was more effective for eosinophil apoptosis than that of HDM IgE-negative (-) asthmatic serum. HDM IgE+ asthmatic serum inhibited both HDM IgE- and HDM IgE+ normal eosinophil apoptosis, and HDM IgE- asthmatic serum suppressed eosinophil apoptosis of HDM IgE+ normal. HDM IgE- normal serum did not inhibit either HDM IgE- or HDM IgE+ normal eosinophil apoptosis, and HDM IgE+ normal serum inhibited HDM IgE+ normal eosinophil apoptosis. The kind of HDM IgE (Dermatophagoides pteronissinus-specific IgE and Dermatophagoides farinae-specific IgE) was not related to the effect of asthmatic serum on eosinophil apoptosis. Extracts of DP and DF, Der p1, and Der p2, were not effective for eosinophil apoptosis. HDM IgE+ asthmatic serum inhibited cleavage of procaspase 9 and procaspase 3. Asthmatic serum induced Akt and ERK phosphorylation, and ERK activation was suppressed by AKTi. Taken together, asthmatic serum inhibited normal eosinophil apoptosis via PI3K/Akt/ERK cascade. The novel approach taken in this study provided better insight into HDM-associated anti-apoptotic mechanism of eosinophils in patients with asthma.

摘要

我们研究了哮喘患者血清对正常个体嗜酸性粒细胞凋亡的影响。哮喘患者血清可抑制正常个体嗜酸性粒细胞凋亡，而正常血清则无此作用。基于屋尘螨（HDM）IgE 的存在进行详细分析后发现，HDM IgE 阳性（+）哮喘患者血清比 HDM IgE 阴性（-）哮喘患者血清更能有效抑制嗜酸性粒细胞凋亡。HDM IgE+哮喘患者血清可抑制 HDM IgE-和 HDM IgE+正常嗜酸性粒细胞凋亡，而 HDM IgE-哮喘患者血清则抑制 HDM IgE+正常嗜酸性粒细胞凋亡。HDM IgE-正常血清对 HDM IgE-和 HDM IgE+正常嗜酸性粒细胞凋亡均无抑制作用，而 HDM IgE+正常血清则抑制 HDM IgE+正常嗜酸性粒细胞凋亡。HDM IgE 的种类（屋尘螨特异性 IgE1 和屋尘螨特异性 IgE2）与哮喘患者血清对嗜酸性粒细胞凋亡的影响无关。DP 和 DF 的提取物、Der p1 和 Der p2 对嗜酸性粒细胞凋亡均无作用。HDM IgE+哮喘患者血清可抑制前半胱氨酸天冬氨酸蛋白酶 9 和前半胱氨酸天冬氨酸蛋白酶 3 的切割。哮喘患者血清可诱导 Akt 和 ERK 磷酸化，而 ERK 激活可被 AKTi 抑制。综上所述，哮喘患者血清通过 PI3K/Akt/ERK 级联抑制正常嗜酸性粒细胞凋亡。本研究采用的新方法使我们对哮喘患者中 HDM 相关嗜酸性粒细胞抗凋亡机制有了更好的了解。

相似文献

[1]
Different anti-apoptotic effects of normal and asthmatic serum on normal eosinophil apoptosis depending on house dust mite-specific IgE.

Mol Biol Rep. 2013-9-25

[2]
House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4.

PLoS One. 2015-5-14

[3]
Regulation of constitutive neutrophil apoptosis due to house dust mite allergen in normal and allergic rhinitis subjects.

PLoS One. 2014-9-22

[4]
Total and allergen-specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites.

Pediatr Allergy Immunol. 2003-12

[5]
House dust mite-specific IgE antibodies in induced sputum are associated with sputum eosinophilia in mite-sensitive asthmatics.

Ann Allergy Asthma Immunol. 2000-8

[6]
[The correlation between the seasonal variation of house dust mite allergens exposure level in household and the level of asthma control in asthmatic children].

Zhonghua Er Ke Za Zhi. 2014-3

[7]
Sensitization to major Dermatophagoides pteronyssinus allergens in house dust mite allergic patients from North Eastern Poland developing rhinitis or asthma.

Adv Med Sci. 2020-9

[8]
Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics.

Allergy. 2011-9-29

[9]
Der p 1 and Der p 2 induce less severe late asthmatic responses than native Dermatophagoides pteronyssinus extract after a similar early asthmatic response.

Clin Exp Allergy. 2001-5

[10]
Differential effect of CCL2 on constitutive neutrophil apoptosis between normal and asthmatic subjects.

J Cell Physiol. 2012-6

引用本文的文献

[1]
Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from .

Int J Mol Sci. 2021-8-5

[2]
Real-life effects of benralizumab on allergic chronic rhinosinusitis and nasal polyposis associated with severe asthma.

Int J Immunopathol Pharmacol. 2020

[3]
Evolution of our view on the IgE molecule role in bronchial asthma and the clinical effect of its modulation by omalizumab: Where do we stand today?

Int J Immunopathol Pharmacol. 2020

[4]
Omalizumab, the first available antibody for biological treatment of severe asthma: more than a decade of real-life effectiveness.

Ther Adv Respir Dis. 2018

[5]
Regulation of constitutive neutrophil apoptosis due to house dust mite allergen in normal and allergic rhinitis subjects.

PLoS One. 2014-9-22

本文引用的文献

[1]
Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects.

J Allergy Clin Immunol. 2013-2

[2]
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.

Am J Respir Crit Care Med. 2012-1-20

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PLoS One. 2011-9-30

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