c-myc调控基因mrl编码纤溶酶原激活物抑制剂1。
The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.
作者信息
Prendergast G C, Diamond L E, Dahl D, Cole M D
机构信息
Department of Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544-1014.
出版信息
Mol Cell Biol. 1990 Mar;10(3):1265-9. doi: 10.1128/mcb.10.3.1265-1269.1990.
Abstract
The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.
摘要
c-myc调控基因mrl的DNA序列（G.C.普伦德加斯特和M.D.科尔，《分子与细胞生物学》9:124 - 134，1989年）显示，它编码纤溶酶原激活物抑制剂1（PAI-1），一种细胞外蛋白水解的调节因子。对人和小鼠PAI-1启动子及cDNA 3'非编码区的比较揭示了几个高度保守的序列结构域，它们是c-myc和其他影响PAI-1表达的因子的潜在作用靶点。我们讨论了PAI-1在正常和肿瘤细胞生长控制中的可能作用。
相似文献
1
The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.c-myc调控基因mrl编码纤溶酶原激活物抑制剂1。
Mol Cell Biol. 1990 Mar;10(3):1265-9. doi: 10.1128/mcb.10.3.1265-1269.1990.
2
Structure and expression of the murine N-myc gene.小鼠N-myc基因的结构与表达
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1827-31. doi: 10.1073/pnas.83.6.1827.
3
alpha 2-Antiplasmin and plasminogen activator inhibitors in healing human skin wounds.α2-抗纤溶酶与纤溶酶原激活物抑制剂在人类皮肤伤口愈合中的作用
Arch Dermatol Res. 1996 Mar;288(3):122-8. doi: 10.1007/BF02505820.
4
Isolation and characterization of the rat plasminogen activator inhibitor-1 gene.大鼠纤溶酶原激活物抑制剂-1基因的分离与鉴定
J Biol Chem. 1990 Feb 5;265(4):2078-85.
5
Xenopus laevis c-myc I and II genes: molecular structure and developmental expression.非洲爪蟾c-myc I和II基因：分子结构与发育表达
Nucleic Acids Res. 1991 Jun 11;19(11):3081-8. doi: 10.1093/nar/19.11.3081.
6
Do products of the myc proto-oncogene play a role in transcriptional regulation of the prothymosin alpha gene?原癌基因myc的产物在胸腺素α原基因的转录调控中起作用吗？
Mol Cell Biol. 1995 Dec;15(12):6999-7009. doi: 10.1128/MCB.15.12.6999.
7
Plasminogen activator inhibitor type 2 contains mRNA instability elements within exon 4 of the coding region. Sequence homology to coding region instability determinants in other mRNAs.2型纤溶酶原激活物抑制剂在编码区的外显子4内含有mRNA不稳定元件。与其他mRNA中编码区不稳定决定因素的序列同源性。
J Biol Chem. 2001 Apr 27;276(17):13675-84. doi: 10.1074/jbc.M010627200. Epub 2001 Jan 26.
8
9
Nucleotide sequence of the first exon of the rat c-myc gene: proviral insertions in murine leukemia virus-induced lymphomas do not affect exon 1.大鼠c-myc基因第一个外显子的核苷酸序列：鼠白血病病毒诱导的淋巴瘤中的前病毒插入不影响外显子1。
Virology. 1988 May;164(1):55-63. doi: 10.1016/0042-6822(88)90619-8.
10
Lc, a member of the maize R gene family responsible for tissue-specific anthocyanin production, encodes a protein similar to transcriptional activators and contains the myc-homology region.Lc是玉米R基因家族的成员，负责组织特异性花青素的产生，它编码一种类似于转录激活因子的蛋白质，并含有myc同源区域。
Proc Natl Acad Sci U S A. 1989 Sep;86(18):7092-6. doi: 10.1073/pnas.86.18.7092.
引用本文的文献
1
Vascular Regulation by Super Enhancer-Derived LINC00607.超级增强子衍生的LINC00607对血管的调控
Front Cardiovasc Med. 2022 Jun 28;9:881916. doi: 10.3389/fcvm.2022.881916. eCollection 2022.
2
Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice.纤溶酶原激活物抑制剂 1（PAI-1/Serpine1）基因敲除小鼠修复伸肌腱过程中细胞信号通路的转录组学分析。
J Orthop Res. 2020 Jan;38(1):43-58. doi: 10.1002/jor.24448. Epub 2019 Sep 1.
3
Plasminogen Activator Inhibitor 1 for Predicting Sepsis Severity and Mortality Outcomes: A Systematic Review and Meta-Analysis.纤溶酶原激活物抑制剂 1 预测脓毒症严重程度和死亡结局的价值：系统评价和荟萃分析。
Front Immunol. 2018 Jun 18;9:1218. doi: 10.3389/fimmu.2018.01218. eCollection 2018.
4
Functional stability of plasminogen activator inhibitor-1.纤溶酶原激活物抑制剂-1的功能稳定性
ScientificWorldJournal. 2014;2014:858293. doi: 10.1155/2014/858293. Epub 2014 Oct 15.
5
MYC and the art of microRNA maintenance.MYC与微小RNA维持的奥秘
Cold Spring Harb Perspect Med. 2014 Apr 15;4(8):a014175. doi: 10.1101/cshperspect.a014175.
6
The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases.纤溶酶原激活物抑制剂1在肾脏疾病和心血管疾病中的作用。
Nat Rev Nephrol. 2009 Apr;5(4):203-11. doi: 10.1038/nrneph.2009.15.
7
Analysis of c-myc, PAI-1 and uPAR in patients with incisional hernias.
Hernia. 2008 Jun;12(3):285-8. doi: 10.1007/s10029-007-0311-7. Epub 2007 Dec 4.
8
Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis.氧化应激、纤溶酶原激活物抑制剂1与肺纤维化
Antioxid Redox Signal. 2008 Feb;10(2):303-19. doi: 10.1089/ars.2007.1903.
9
Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter.谷胱甘肽通过抑制p38和JNK丝裂原活化蛋白激酶以及AP-1、SP-1和Smad与纤溶酶原激活物抑制剂-1（PAI-1）启动子的结合，来抑制转化生长因子-β（TGF-β）诱导的PAI-1表达。
Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1281-92. doi: 10.1152/ajplung.00128.2007. Epub 2007 Sep 21.
10
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.纤溶酶原激活物抑制剂-1是p53在诱导复制性衰老过程中的关键下游靶点。
Nat Cell Biol. 2006 Aug;8(8):877-84. doi: 10.1038/ncb1448. Epub 2006 Jul 23.
本文引用的文献
1
Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.牛内皮细胞产生的一种异常稳定的纤溶抑制剂的检测。
Proc Natl Acad Sci U S A. 1983 May;80(10):2956-60. doi: 10.1073/pnas.80.10.2956.
2
Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.内皮细胞合成的纤溶酶原激活物抑制剂（抗激活物）的纯化
J Biol Chem. 1984 Dec 10;259(23):14914-21.
3
The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related.内皮细胞、血小板、血清和血浆中的主要纤溶酶原激活物抑制剂在免疫学上相关。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8710-4. doi: 10.1073/pnas.82.24.8710.
4
A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor.
Science. 1987 Nov 27;238(4831):1269-71. doi: 10.1126/science.3685976.
5
The regulation and expression of c-myc in normal and malignant cells.
Annu Rev Immunol. 1986;4:317-38. doi: 10.1146/annurev.iy.04.040186.001533.
6
7
Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.一组生长相关即刻早期基因在BALB/c 3T3细胞中的表达：与c-fos或c-myc的协同调控
Proc Natl Acad Sci U S A. 1987 Mar;84(5):1182-6. doi: 10.1073/pnas.84.5.1182.
8
Identification of growth-factor-inducible genes in mouse fibroblasts.
Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:901-5. doi: 10.1101/sqb.1988.053.01.103.
9
Cell-associated plasminogen activation: regulation and physiological functions.
Annu Rev Cell Biol. 1988;4:93-126. doi: 10.1146/annurev.cb.04.110188.000521.
10
Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences.人纤溶酶原激活物抑制剂-1基因。启动子和结构基因核苷酸序列。
J Biol Chem. 1988 Jul 5;263(19):9129-41.
Zotero 插件