托美丁在大鼠、猴和人体内的代谢。
Metabolism of tolmetin in rat, monkey, and man.
作者信息
Sumner D D, Dayton P G, Cucinell S A, Plostnieks J
出版信息
Drug Metab Dispos. 1975 Jul-Aug;3(4):283-6.
PMID:240658
Abstract
5-p-Carboxybenzoyl-1-methylpyrrole-2-acetic acid has been identified in the rat, monkey, and man as the major urinary metabolite of tolmetin, a new nonsteroidal anti-inflammatory agent. Conjugation of tolmetin, a major mode of disposition in man and monkey, was not observed in the rat.
摘要
5-对羧基苯甲酰基-1-甲基吡咯-2-乙酸已在大鼠、猴子和人类中被鉴定为新型非甾体抗炎药托美汀的主要尿液代谢物。在大鼠中未观察到托美汀的结合反应，而结合反应是人和猴子体内托美汀的主要代谢途径。
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