Sansom A J, Darlington C L, Smith P F
Department of Psychology, University of Otago, Dunedin, New Zealand.
Neuropharmacology. 1990 Jan;29(1):83-4. doi: 10.1016/0028-3908(90)90087-8.
Guinea pigs which had compensated for a unilateral labyrinthectomy exhibited a loss of ocular motor and postural compensation when a 40 or 20 mM concentration of the NMDA antagonist CPP, was injected through a cannula implanted in the IVth ventricle close to the vestibular nuclei. Similar injections of artificial cerebrospinal fluid did not induce loss of compensation. These results suggest that NMDA receptors may contribute to vestibular compensation in the guinea pig.
已经代偿单侧迷路切除术的豚鼠，当通过植入靠近前庭核的第四脑室的套管注射40或20 mM浓度的NMDA拮抗剂CPP时，出现眼动和姿势代偿丧失。注射人工脑脊液则不会导致代偿丧失。这些结果表明，NMDA受体可能参与豚鼠的前庭代偿。
