Guan Zhengrong, Fellner Robert C, Van Beusecum Justin, Inscho Edward W
Department of Physiology, Medical College of Georgia, Georgia Regents University, 1120 15th Street, Augusta, Georgia 30912-3000.
Curr Vasc Pharmacol. 2014;12(6):818-28. doi: 10.2174/15701611113116660152.
Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood. The work of many investigators has provided insights into many aspects of the autoregulatory mechanism, but many critical components remain elusive. This review is intended to update the reader on the role of P2 purinoceptors as a postulated mechanism responsible for renal autoregulatory resistance adjustments. It will summarize recent advances in normal function and it will touch on more recent ideas regarding autoregulatory insufficiency in hypertension and inflammation. Current thoughts on the nature of the mechanosensor responsible for myogenic behavior will be also be discussed as well as current thoughts on the mechanisms involved in ATP release to the extracellular fluid space.
肾血流和肾小球滤过率的自身调节是肾微循环的一项基本功能。虽然这一现象已为人所知多年，但其调节系统背后的确切机制仍知之甚少。许多研究者的工作为自身调节机制的诸多方面提供了见解，但许多关键组成部分仍不明确。本综述旨在向读者介绍P2嘌呤受体作为一种假定机制在肾自身调节阻力调节中的作用。它将总结正常功能方面的最新进展，并涉及关于高血压和炎症中自身调节功能不全的最新观点。还将讨论关于负责肌源性行为的机械感受器性质的当前观点，以及关于ATP释放到细胞外液空间的机制的当前观点。
