Dipartimento di Scienze Otorinolaringoiatriche e Oftalmologiche, Universita' Cattolica del Sacro Cuore, Lgo F, Vito 1, 00168 Roma, Italy.
J Transl Med. 2013 Sep 25;11:228. doi: 10.1186/1479-5876-11-228.
To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes.
Thirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6-12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures.
After three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes.
The present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.
为了确定天然化合物藏红花的口服补充对早期年龄相关性黄斑变性的神经保护作用是否受补体因子 H (CFH) 和年龄相关性黄斑变性易感性 2 (ARMS2) 风险基因型的影响。
对 33 名早期 AMD 患者进行 CFH(rs1061170)和 ARMS2(rs10490924)多态性筛查，并接受藏红花口服补充(20mg/天)，平均治疗时间为 11 个月(范围为 6-12 个月)，通过临床检查和焦点视网膜电图(fERG)衍生的黄斑(18°)闪烁敏感性估计进行纵向评估。fERG 幅度和黄斑敏感性，即估计的 fERG 幅度阈值的倒数，是主要的观察指标。
补充三个月后，与基线值相比，平均 fERG 幅度和 fERG 敏感性显著提高(p<0.01)。这些变化在整个随访期间保持稳定。在不同的 CFH 或 ARMS2 基因型之间，临床和 fERG 改善没有显著差异。
本研究结果表明，藏红花补充对个体 AMD 患者的功能作用与疾病的主要风险基因型无关。
