Mauch C, Kreig T
Department of Dermatology, University of Munich, West Germany.
Rheum Dis Clin North Am. 1990 Feb;16(1):93-107.
The extracellular matrix has a complex structure which provides the scaffold of the connective tissue and influences many cellular functions. Fibroblast attachment, chemotaxis, and proliferation depend on the interaction of the cells with different components of the extracellular matrix. In addition, biosynthetic activities including protein and collagen synthesis are regulated by a two- or three-dimensional contact of fibroblasts with the surrounding matrix. Since scleroderma is characterized by an excessive deposition of collagen in the involved organs, many attempts have been made to define the altered cellular metabolism on a molecular level. This review summarized the role of fibroblast matrix interaction for the control of fibroblast functions during physiological processes and their activation in fibrosis.
细胞外基质具有复杂的结构，它为结缔组织提供支架并影响许多细胞功能。成纤维细胞的附着、趋化性和增殖取决于细胞与细胞外基质不同成分的相互作用。此外，包括蛋白质和胶原蛋白合成在内的生物合成活动受成纤维细胞与周围基质的二维或三维接触调节。由于硬皮病的特征是受累器官中胶原蛋白过度沉积，因此人们已进行了许多尝试，试图在分子水平上确定细胞代谢的改变。本综述总结了成纤维细胞与基质相互作用在生理过程中对成纤维细胞功能的控制作用及其在纤维化中的激活作用。
