Krieg T, Heckmann M
Recenti Prog Med. 1989 Nov;80(11):594-8.
Fibroblasts are mesenchymal cells present in most organs which play a crucial role in repair processes but are also involved in the development of fibrosis. Although fibroblasts have been grown in culture for many years, their multiple functions including migration, chemotaxis, protein synthesis and others have only recently been investigated in detail. These studies demonstrated that cellular responses of fibroblasts can be elicited by matrix-mediated signals as well as by cytokines released from inflammatory or other differentiated cells. The aim of the present paper is to review the influence of such signals and to discuss their role in disease processes, particularly in fibrosis, keloids or scleroderma.
成纤维细胞是存在于大多数器官中的间充质细胞，在修复过程中起关键作用，但也参与纤维化的发展。尽管成纤维细胞已在体外培养多年，但其包括迁移、趋化性、蛋白质合成等在内的多种功能直到最近才得到详细研究。这些研究表明，成纤维细胞的细胞反应可由基质介导的信号以及炎症或其他分化细胞释放的细胞因子引发。本文旨在综述此类信号的影响，并讨论它们在疾病过程中的作用，特别是在纤维化、瘢痕疙瘩或硬皮病中的作用。
