Department of Gynecological Endocrinology and Fertility Disorders, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany,
Arch Gynecol Obstet. 2013 Nov;288(5):971-5. doi: 10.1007/s00404-013-3033-3.
In vitro maturation is a technique of assisted reproduction which in contrast to standard IVF or ICSI almost fully avoids hormonal stimulation. Immature oocytes will be fully matured in vitro within 24 h after oocyte collection. The method was introduced in the early nineties and is indicated in patients at high risk for ovarian hyperstimulation. Results are almost comparable to standard techniques. Up to now no elevated risk for fetal malformations has been described. IVM is a suitable alternative in IVF for an exactly defined subgroup of patients, in particular patients with PCOS, but still does not replace standard techniques.
体外成熟是一种辅助生殖技术，与标准的体外受精或卵胞浆内单精子注射相比，它几乎完全避免了激素刺激。不成熟的卵母细胞将在卵母细胞采集后 24 小时内完全在体外成熟。该方法于 90 年代初引入，适用于卵巢过度刺激高风险的患者。结果几乎与标准技术相当。到目前为止，尚未描述胎儿畸形风险增加。对于确切定义的亚组患者，IVM 是 IVF 的一种合适替代方法，特别是多囊卵巢综合征患者，但仍不能替代标准技术。
