Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan 250012, China.
Oxid Med Cell Longev. 2021 Jul 29;2021:6668365. doi: 10.1155/2021/6668365. eCollection 2021.
Oxidative stress has been recognized as one of the causal mediators of female infertility by affecting the oocyte quality and early embryo development. Improving oxidative stress is essential for reproductive health. Melatonin, a self-secreted antioxidant, has a wide range of effects by improving mitochondrial function and reducing the damage of reactive oxygen species (ROS). This minireview illustrates the applications of melatonin in reproduction from four aspects: physiological ovarian aging, vitrification freezing, maturation (IVM), and oxidative stress homeostasis imbalance associated with polycystic ovary syndrome (PCOS), emphasising the role of melatonin in improving the quality of oocytes in assisted reproduction and other adverse conditions.
氧化应激被认为是导致女性不孕的原因之一，它会影响卵子质量和早期胚胎发育。改善氧化应激对于生殖健康至关重要。褪黑素作为一种内源性抗氧化剂，通过改善线粒体功能和减少活性氧（ROS）的损伤，具有广泛的作用。本综述从四个方面阐述了褪黑素在生殖中的应用：生理性卵巢衰老、玻璃化冷冻、成熟（IVM）以及与多囊卵巢综合征（PCOS）相关的氧化应激平衡失调，强调了褪黑素在改善辅助生殖和其他不良条件下卵子质量中的作用。
