College of Pharmacy, Duksung Women's University, Seoul, 132-714, Korea.
Arch Pharm Res. 2014 Apr;37(4):452-8. doi: 10.1007/s12272-013-0244-x. Epub 2013 Sep 26.
A new series of 3-allylseleno-6-alkylthiopyridazines 6a-6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e.
通过两条从 3,6-二氯哒嗪出发的合成路线，合成了一系列新的 3-烯丙基硒基-6-烷基噻吩并[2,3-d]嘧啶 6a-6g，旨在开发新的抗癌药物。这些新化合物在 CCK-8 测定中对乳腺癌（MCF-7）细胞表现出抗增殖活性，可能是治疗癌的有前途的候选药物。化合物 6e（3-烯丙基硒基-6-戊基噻吩并[2,3-d]嘧啶）在抑制这些细胞系的生长方面显示出比 5FU 更高的效力。这表明化合物 6e 具有潜在的抗癌活性。
