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超越抗氧化剂的有机硒化合物。

Organoselenium compounds beyond antioxidants.

作者信息

Mamgain Ritu, Mishra Garima, Kriti Saumya, Singh Fateh V

机构信息

Chemistry Division, School of Advanced Sciences (SAS), Vellore Institute of Technology - Chennai, Chennai, India.

Department of Chemistry, Western Illinois University-Quad Cities, Moline, IL, USA.

出版信息

Future Med Chem. 2024 Dec;16(24):2663-2685. doi: 10.1080/17568919.2024.2435254. Epub 2024 Dec 22.

Abstract

Organoselenium chemistry has become a significant field due to its role in synthesizing numerous biologically active and therapeutic compounds. In early phase, researchers focused on designing organoselenium compounds with antioxidant properties and were quite successful. In last two decades, synthetic chemists shifted their focus toward synthesis of organoselenium compounds with biological properties, moving beyond their traditional antioxidant properties. The review includes synthesis and study of organo-selenium compounds as anticancer, antimicrobial, antiviral, antidiabetic, antithyroid, anti-inflammatory therapies, contributing to disease treatment. This review covers the synthesis and medicinal applications of synthetic organoselenium compounds over the past 10 years, thus making it a valuable resource for researchers in the field of medicinal chemistry.

摘要

有机硒化学因其在合成众多生物活性和治疗性化合物中的作用而成为一个重要领域。在早期阶段,研究人员专注于设计具有抗氧化特性的有机硒化合物,并取得了相当大的成功。在过去二十年中,合成化学家将重点转向具有生物学特性的有机硒化合物的合成,超越了其传统的抗氧化特性。该综述涵盖了作为抗癌、抗菌、抗病毒、抗糖尿病、抗甲状腺、抗炎疗法的有机硒化合物的合成与研究,有助于疾病治疗。本综述涵盖了过去10年合成有机硒化合物的合成及药用应用,因此使其成为药物化学领域研究人员的宝贵资源。

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