Saint-Hilaire J M
Service de neurologie, hôpital Notre-Dame, Montréal, Québec, Canada.
Rev Prat. 1990 Feb 1;40(4):312-8.
The indications of surgery for epilepsy are: 1) resistance to medical treatment; 2) well-localized cortical focus, and 3) possibility of removing the focus without creating a significant functional deficit. Presurgical evaluation is initially clinical: correlations between the clinical manifestations recorded on videotapes and EEG tracings, neurological and neuropsychological examinations, intra-carotid amytal test. Interictal and, preferably, ictal EEG recording on the scalp and in depth is the fundamental procedure used to locate epileptogenic areas. The most reliable locating examination is the recording of a spontaneous seizure by means of implanted electrodes. Recent or old lesions responsible for epilepsy can be detected by arteriography, ventriculography, CT scans and, more recently, nuclear magnetic resonance. PET scan and SPECT are not commonly used. The ideal operation is cortectomy which gives the best long-term results (87 p. 100 in temporal lobe epilepsy). When cortectomy is not feasible, complete or partial (anterior two-thirds) callosotomy can be of considerable help in some forms of epilepsy with frequent falls and generalized seizures. On the whole, it seems that the surgical treatment of epilepsy is grossly underused.
1)药物治疗无效;2)皮质病灶定位明确;3)切除病灶而不造成明显功能缺损的可能性。术前评估首先是临床评估:录像记录的临床表现与脑电图描记、神经及神经心理学检查、颈动脉内阿米妥试验之间的相关性。头皮及深部的发作间期及最好是发作期脑电图记录是用于定位致痫区的基本检查方法。最可靠的定位检查是通过植入电极记录自发发作。导致癫痫的新旧病灶可通过动脉造影、脑室造影、CT扫描以及最近的核磁共振来检测。PET扫描和SPECT一般不常用。理想的手术是皮质切除术,其长期效果最佳(颞叶癫痫的有效率为87%)。当皮质切除术不可行时,完全或部分(前三分之二)胼胝体切开术对某些频繁跌倒和全身性发作的癫痫类型可能有很大帮助。总体而言,癫痫的外科治疗似乎未得到充分利用。