Horn T, Svendsen L B, Nielsen R
Dept. of Pathology and Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark.
Scand J Gastroenterol. 1990 Jan;25(1):66-72. doi: 10.3109/00365529008999211.
Four cases of brown-bowel syndrome (BBS) are presented. BBS is found in malabsorptive conditions secondary to diseases involving the liver, pancreas, and gastrointestinal tract. Morphologically, BBS is characterized by deposition of lipofuscin in the tunica muscularis, and electron microscopy shows degradation of smooth-muscle cell mitochondria. It is probable that BBS is a manifestation of vitamin E deficiency causing smooth-muscle cell 'mitochondrial myopathy'. Normal bowel function is retained, causing bowel hypotonia, and an aggravation of the underlying disease occurs. On suspicion of BBS, diagnosis is obtained in full-wall biopsy specimens of the intestine.
本文报告了4例棕色肠综合征（BBS）。BBS见于继发于肝脏、胰腺和胃肠道疾病的吸收不良状态。形态学上，BBS的特征是脂褐素在肌层沉积，电子显微镜显示平滑肌细胞线粒体退化。BBS可能是维生素E缺乏导致平滑肌细胞“线粒体肌病”的一种表现。肠道功能保持正常，导致肠张力减退，并且基础疾病会加重。怀疑有BBS时，可通过肠道全层活检标本做出诊断。
