麻醉药物在肝脏细胞凋亡中的作用。
The role of anesthetic drugs in liver apoptosis.
作者信息
Dabbagh Ali, Rajaei Samira
机构信息
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
出版信息
Hepat Mon. 2013 Aug 25;13(8):e13162. doi: 10.5812/hepatmon.13162.
CONTEXT
The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver.
EVIDENCE ACQUISITION
The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern during the last years; especially considering the neurologic system.
RESULTS
However, we have evidence that there is some concern regarding their effects on the liver cells. Fortunately not all the anesthetics are blamed and even some could be used safely, based on the available evidence.
CONCLUSIONS
Besides, there are some novel agents, yet under research, which could affect the future of anesthetic agents' fate regarding their hepatic effects.
背景
现代麻醉实践高度依赖于一组麻醉药物，其中许多药物在肝脏中代谢。
证据获取
当然，肝脏通常能够承受这种负担。然而，这并非总是一成不变的规律。在过去几年中，麻醉诱导的细胞凋亡引起了极大关注；尤其是考虑到神经系统。
结果
然而，我们有证据表明人们对它们对肝细胞的影响存在一些担忧。幸运的是，并非所有麻醉剂都受到指责，根据现有证据，甚至有些麻醉剂可以安全使用。
结论
此外，还有一些仍在研究中的新型药物，它们可能会影响麻醉药物在肝脏作用方面的未来发展。
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