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生育三烯酚佐剂树突状细胞抑制肿瘤生长和转移：乳腺癌的小鼠模型。

Tocotrienol-adjuvanted dendritic cells inhibit tumor growth and metastasis: a murine model of breast cancer.

机构信息

Pathology Division, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia ; Nutrition Unit, Malaysian Palm Oil Board, Bandar Baru Bangi, Selangor, Malaysia.

出版信息

PLoS One. 2013 Sep 19;8(9):e74753. doi: 10.1371/journal.pone.0074753. eCollection 2013.

DOI:10.1371/journal.pone.0074753
PMID:24069344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3777960/
Abstract

Tocotrienol-rich fraction (TRF) from palm oil is reported to possess anti-cancer and immune-enhancing effects. In this study, TRF supplementation was used as an adjuvant to enhance the anti-cancer effects of dendritic cells (DC)-based cancer vaccine in a syngeneic mouse model of breast cancer. Female BALB/c mice were inoculated with 4T1 cells in mammary pad to induce tumor. When the tumor was palpable, the mice in the experimental groups were injected subcutaneously with DC-pulsed with tumor lysate (TL) from 4T1 cells (DC+TL) once a week for three weeks and fed daily with 1 mg TRF or vehicle. Control mice received unpulsed DC and were fed with vehicle. The combined therapy of using DC+TL injections and TRF supplementation (DC+TL+TRF) inhibited (p<0.05) tumor growth and metastasis. Splenocytes from the DC+TL+TRF group cultured with mitomycin-C (MMC)-treated 4T1 cells produced higher (p<0.05) levels of IFN-γ and IL-12. The cytotoxic T-lymphocyte (CTL) assay also showed enhanced tumor-specific killing (p<0.05) by CD8(+) T-lymphocytes isolated from mice in the DC+TL+TRF group. This study shows that TRF has the potential to be used as an adjuvant to enhance effectiveness of DC-based vaccines.

摘要

富含生育三烯酚的棕榈油提取物 (TRF) 据称具有抗癌和增强免疫的作用。在这项研究中，TRF 补充剂被用作佐剂，以增强树突状细胞 (DC) 为基础的癌症疫苗在乳腺癌同基因小鼠模型中的抗癌效果。雌性 BALB/c 小鼠在乳腺垫中接种 4T1 细胞以诱导肿瘤。当肿瘤可触及时，实验组小鼠每周一次皮下注射用 4T1 细胞肿瘤裂解物 (TL) 脉冲的 DC (DC+TL) ，共三周，并每天给予 1mg TRF 或载体。对照小鼠接受未脉冲的 DC 并给予载体。使用 DC+TL 注射和 TRF 补充剂的联合治疗（DC+TL+TRF）抑制了肿瘤生长和转移（p<0.05）。用丝裂霉素 C（MMC）处理的 4T1 细胞培养的来自 DC+TL+TRF 组的脾细胞产生了更高水平的 IFN-γ 和 IL-12（p<0.05）。CTL 测定也显示，来自 DC+TL+TRF 组小鼠的 CD8+T 淋巴细胞对肿瘤的特异性杀伤作用增强（p<0.05）。这项研究表明，TRF 有可能被用作佐剂来增强基于 DC 的疫苗的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/cbc5b09fa50e/pone.0074753.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/6874267c30a9/pone.0074753.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/1542eb071f2b/pone.0074753.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/3cba2ed7f693/pone.0074753.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/b511fa9b5041/pone.0074753.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/6757e357d0e2/pone.0074753.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/cbc5b09fa50e/pone.0074753.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/6874267c30a9/pone.0074753.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/1542eb071f2b/pone.0074753.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/3cba2ed7f693/pone.0074753.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/b511fa9b5041/pone.0074753.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/6757e357d0e2/pone.0074753.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ab4/3777960/cbc5b09fa50e/pone.0074753.g006.jpg

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