免疫系统在骨转移发病机制中的贡献。
The Contribution of the Immune System in Bone Metastasis Pathogenesis.
机构信息
State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, China.
Breast & Ovarian Cancer Program, Department of Oncology, The Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.
出版信息
Int J Mol Sci. 2019 Feb 25;20(4):999. doi: 10.3390/ijms20040999.
Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche for disseminated tumor cells to colonize and proliferate. In this unique immune milieu, multiple immune cells including T cells, natural killer cells, macrophages, dendritic cells, myeloid-derived suppressor cells, and neutrophils are involved in the process of bone metastasis. In this review, we will discuss the crosstalk between immune cells in bone microenvironment and their involvement with cancer cell metastasis to the bone. Furthermore, we will highlight the anti-tumoral and pro-tumoral function of each immune cell type that contributes to bone metastasis. We will end with a discussion of current therapeutic strategies aimed at sensitizing immune cells.
骨转移与癌症患者的显著发病率有关，并导致生活质量下降。骨髓是一个肥沃的土壤，含有复杂的免疫细胞组成，可能为播散的肿瘤细胞提供一个免疫特权的小生境，使其定植和增殖。在这种独特的免疫环境中，包括 T 细胞、自然杀伤细胞、巨噬细胞、树突状细胞、髓系来源的抑制细胞和中性粒细胞在内的多种免疫细胞参与了骨转移的过程。在这篇综述中，我们将讨论骨微环境中免疫细胞之间的相互作用及其与癌细胞向骨转移的关系。此外，我们将强调每种免疫细胞类型的抗肿瘤和促肿瘤功能，这些功能有助于骨转移。最后，我们将讨论旨在使免疫细胞敏感化的当前治疗策略。
Zotero 插件