Eleutheriou Benizelou 106 Kallithea 17676, Athens, Greece.
Anticancer Agents Med Chem. 2014 Feb;14(2):290-5. doi: 10.2174/18715206113136660339.
Recent data have shown strong chemopreventive and possibly cancer chemotherapeutic effects of green tea polyphenols against cancer. Despite advances in breast cancer treatment, mortality from breast cancer is still high. Undoubtedly novel treatment strategies are needed for chemoprevention of high risk women and for the treatment of receptor negative breast cancer. Green tea catechins have been shown to inhibit proliferation of breast cancer cells and to block carcinogenesis. This review attempts a critical presentation of the mechanisms of action of green tea catechins in breast cancer. Several mechanisms of action of green tea catechins in breast cancer have been proposed including modulation of extracellular signalling, induction of apoptosis through redox regulation, or through modulation of epigenetic alterations. A number of molecular targets of green tea catechins have been suggested i.e molecular chaperones, telomerase, apoptotic cascade. Although the molecular links among the proposed mechanisms of action of green tea catechins are often missing, it must be emphasized that all the proposed mechanisms indicate that green tea catechins inhibit growth and /or promote apoptosis. It would be interesting if future experimental trials could take into account that green tea catechins are multi-target agents and attempt to link every novel proposed target with the other already proposed targets of green tea catechins.
最近的数据表明，绿茶多酚对癌症具有很强的化学预防作用，并且可能具有癌症化疗作用。尽管乳腺癌的治疗取得了进展，但乳腺癌的死亡率仍然很高。毫无疑问，需要新的治疗策略来预防高危女性的癌症和治疗受体阴性乳腺癌。绿茶儿茶素已被证明可抑制乳腺癌细胞的增殖并阻断癌变。本文试图对绿茶儿茶素在乳腺癌中的作用机制进行批判性介绍。已经提出了绿茶儿茶素在乳腺癌中的几种作用机制，包括调节细胞外信号、通过氧化还原调节诱导细胞凋亡，或通过调节表观遗传改变。已经提出了绿茶儿茶素的许多分子靶标，即分子伴侣、端粒酶、凋亡级联。尽管绿茶儿茶素的拟议作用机制之间的分子联系常常缺失，但必须强调的是，所有拟议的机制都表明绿茶儿茶素抑制生长和/或促进细胞凋亡。如果未来的实验试验能够考虑到绿茶儿茶素是多靶点药物，并尝试将每个新提出的靶标与绿茶儿茶素的其他已提出的靶标联系起来，那将是有趣的。
