Mishra V N, Tripathi C B, Kumar A, Nandmer V, Ansari A Z, Kumar B, Chaurasia R N, Joshi D
Neurol Res. 2014 Jan;36(1):38-40. doi: 10.1179/1743132813Y.0000000258. Epub 2013 Oct 23.
Lathyrism is now rarely seen as a clinical disease in general, medical or neurology outpatient departments, throughout the world. Eating patterns of seeds of Lathyrus sativus are still prevalent focal points in parts of the world. Question arises, why are we not seeing cases of lathyrism? Is it that the disease has changed its profile, with the changing socioeconomic status of the poor or underdeveloped or moderately developed countries? Is it that the seeds of lathyrus are less toxic now? Is it that the body defence against toxins of lathyrus has genetically modified? To find out answers to these interesting questions, an extensive questionnaire-based sampling was done among 1000 subjects from northern India to identify the human behaviour regarding the knowledge, attitude, and practices (KAPs) for L. sativus. Four clinically suspected cases of Lathyrism were also fully worked up. It was concluded that many areas of India are still being fed with lathyrus seeds, but not many cases have appeared. Many questions have to be answered, as to what has reduced the incidence of lathyrism.
目前,在全球范围内,一般内科或神经科门诊中,很少将山黧豆中毒视为一种临床疾病。食用山黧豆种子的饮食习惯在世界部分地区仍然是普遍关注的焦点。问题来了,为什么我们看不到山黧豆中毒的病例呢?是因为随着贫穷、不发达或中等发达国家社会经济状况的变化,这种疾病的特征发生了改变吗?是山黧豆种子现在毒性变小了吗?是人体对山黧豆毒素的防御机制发生了基因改变吗?为了找到这些有趣问题的答案,我们对来自印度北部的1000名受试者进行了广泛的基于问卷调查的抽样,以确定人们对山黧豆的知识、态度和行为(KAPs)。还对4例临床疑似山黧豆中毒病例进行了全面检查。得出的结论是,印度许多地区仍以山黧豆种子为食,但出现的病例并不多。关于是什么降低了山黧豆中毒的发病率,还有许多问题有待解答。