Khandare Arjun L, Babu J J, Ankulu M, Aparna N, Shirfule Amol, Rao G Shankar
Food & Drug Toxicology Centre (ICMR), Hyderabad, India.
Indian J Med Res. 2014 Jul;140(1):96-101.
BACKGROUND & OBJECTIVES: Neurolathyrism is a non progressive motor neuron disorder engendered by the prolonged over-consumption of Lathyrus sativus (grass pea) seeds which contain a neurotoxic amino acid, β-N oxalyl- L-α, β-diaminopropionic acid (β-ODAP). It is characterized by spastic paraparesis in the hind limbs. The present study was conducted in 105 households (HHs) of Gondia district in Maharashtra, India, where grass pea is cultivated and consumed to assess the health implication of its consumption.
Across-sectional survey was carried out in 105 HHS in five villages and grass pea samples were collected for β-ODAP estimation. Amino acid analysis was also done, neurolathyrism cases were identified by snowball sampling method and neurological examination was carried out.
The study revealed that 61 per cent of population was consuming this pulse as a part of diet. β-ODAP concentration in grass pea was high in Bora village (1254.5 ± 528.21 mg %) and less in Malgaon village (413.6±415.79 mg %). The nutritional status of the people was within the normal range (BMI 18± 3.40 kg/m2) in the surveyed households. Consumption of grass pea was observed to be less than 25 g.
The cases of neurolathyrism declined in all the studied villages due to reduced β-ODAP exposure through Lathyrus sativus consumption, however, the grass pea was cultivated and consumed in Gondia district of Maharashtra State.
神经性山黧豆中毒是一种非进行性运动神经元疾病，由长期过量食用含有神经毒性氨基酸β-N-草酰-L-α，β-二氨基丙酸（β-ODAP）的山黧豆（草豌豆）种子引起。其特征为后肢痉挛性轻瘫。本研究在印度马哈拉施特拉邦贡迪亚地区的105户家庭中开展，该地区种植并食用草豌豆，旨在评估食用草豌豆对健康的影响。
在五个村庄的105户家庭中进行了横断面调查，并采集草豌豆样本以测定β-ODAP含量。还进行了氨基酸分析，通过滚雪球抽样法确定神经性山黧豆中毒病例，并进行了神经学检查。
研究显示，61%的人口将这种豆类作为饮食的一部分。博拉村草豌豆中的β-ODAP浓度较高（1254.5±528.21毫克%），马尔冈村则较低（413.6±415.79毫克%）。被调查家庭中人们的营养状况处于正常范围（体重指数18±3.40千克/平方米）。观察到草豌豆的食用量少于25克。
由于食用山黧豆导致的β-ODAP暴露减少，所有研究村庄中神经性山黧豆中毒病例均有所下降，然而，马哈拉施特拉邦贡迪亚地区仍种植并食用草豌豆。
