Alawad Azza O, Merghani Tarig H, Ballal Mansour A
Department of Physiology, Faculty of Medicine, University of Al-Neelain, Khartoum, Sudan.
BMC Res Notes. 2013 Sep 26;6:382. doi: 10.1186/1756-0500-6-382.
Both obesity and type II diabetes mellitus are associated with insulin resistance and abnormal metabolic reactions. This study was conducted to evaluate resting metabolic rate in obese diabetic patients and to assess its relation to glycaemic control.
This is a case control study conducted in Gabir AbuEliz centre in Khartoum, Sudan. A random sample of 40 obese diabetic patients (cases) and 40 obese non-diabetic subjects (controls) were interviewed and examined clinically to exclude presence of acute or chronic medical illness. Haemoglobin A1c was measured for each participant using the "NycoCard Haemoglobin A1c test" (Axis -Shield/ Norway). Fasting blood sugar was measured using one touch(R) glucometer (LifeScan Canada Ltd). The PowerLab 8/35 with a gas analyzer (AD Instruments, Castle Hill Australia) was used for measurement of VO2, VCO2 and Respiratory exchange ratio (RER). Resting metabolic rate was calculated using the Weir equation. VO2 (mean+/-SD) ml/min was significantly higher among cases (209.9+/-42.7) compared to the controls (192.4+/-28.1), (P = 0.034). Similarly, VCO2 (mean+/-SD) ml/min was higher among cases (191.4+/-35.0) than controls (178.3+/-22.5), (P = 0.05). Resting metabolic rate "RMR" (mean+/-SD) kcal/day was higher in obese diabetic patients (1480.7 +/- 274.2) than obese non-diabetic subjects (1362.4+/- 184.8), (P = 0.027). Participants with high glycated haemoglobin had higher RMR than those with normal glycated haemoglobin (P = 0.016).
It is concluded that resting metabolic rate is significantly higher in obese diabetic patients compared to obese non-diabetics, especially in those with poor glycaemic control.
肥胖和II型糖尿病均与胰岛素抵抗及异常代谢反应相关。本研究旨在评估肥胖糖尿病患者的静息代谢率，并评估其与血糖控制的关系。
这是一项在苏丹喀土穆的加比尔·阿布埃利兹中心进行的病例对照研究。随机抽取40名肥胖糖尿病患者（病例组）和40名肥胖非糖尿病受试者（对照组）进行访谈并进行临床检查，以排除急性或慢性疾病。使用“NycoCard糖化血红蛋白检测”（Axis-Shield/挪威）为每位参与者测量糖化血红蛋白A1c。使用One Touch®血糖仪（LifeScan加拿大有限公司）测量空腹血糖。使用配备气体分析仪的PowerLab 8/35（AD Instruments，澳大利亚城堡山）测量VO2、VCO2和呼吸交换率（RER）。使用韦尔方程计算静息代谢率。病例组的VO2（平均值±标准差）ml/min（209.9±42.7）显著高于对照组（192.4±28.1），（P = 0.034）。同样，病例组的VCO2（平均值±标准差）ml/min（191.4±35.0）高于对照组（178.3±22.5），（P = 0.05）。肥胖糖尿病患者的静息代谢率“RMR”（平均值±标准差）kcal/天（1480.7±274.2）高于肥胖非糖尿病受试者（1362.4±184.8），（P = 0.027）。糖化血红蛋白高的参与者的RMR高于糖化血红蛋白正常的参与者（P = 0.016）。
得出的结论是，肥胖糖尿病患者的静息代谢率显著高于肥胖非糖尿病患者，尤其是血糖控制不佳的患者。
