Truscott W M, Cheung A T, Hirsh D C
Department of Veterinary Microbiology, School of Veterinary Medicine, University of California, Davis 95616.
Vet Microbiol. 1990 Jan;21(3):283-90. doi: 10.1016/0378-1135(90)90039-x.
Pasteurella multocida inhibits the uptake and killing of Candida albicans and P. multocida by avian mononuclear phagocytic cells. The toxic outer membrane protein of P. multocida, which has been previously described, also inhibited the uptake and killing of C. albicans. Antibody specific for the toxic outer membrane protein reversed this effect resulting not only in an increase in uptake of C. albicans and P. multocida, but also in intracellular killing of P. multocida. This antibody, however, only partially restored killing of C. albicans. These data support the hypothesis that P. multocida is capable of intracellular survival in avian mononuclear phagocytic cells and that the toxic outer membrane protein is totally or partly responsible for this occurrence.
多杀性巴氏杆菌抑制禽单核吞噬细胞对白色念珠菌和多杀性巴氏杆菌的摄取与杀伤。先前已描述过的多杀性巴氏杆菌有毒外膜蛋白也抑制白色念珠菌的摄取与杀伤。针对有毒外膜蛋白的特异性抗体可逆转这种效应，不仅导致白色念珠菌和多杀性巴氏杆菌摄取增加，还能使细胞内的多杀性巴氏杆菌被杀伤。然而，该抗体仅部分恢复了对白色念珠菌的杀伤作用。这些数据支持以下假说：多杀性巴氏杆菌能够在禽单核吞噬细胞内生存，且有毒外膜蛋白完全或部分导致了这种情况的发生。
