克隆相关的复合滤泡性淋巴瘤和套细胞淋巴瘤，具有临床病理特征和生物学意义。

Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.

机构信息

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230-1439, USA; Department of Pathology, National University Hospital, 119074, Singapore.

出版信息

Hum Pathol. 2013 Dec;44(12):2658-67. doi: 10.1016/j.humpath.2013.07.007. Epub 2013 Sep 24.

DOI:10.1016/j.humpath.2013.07.007

PMID:24071012

Abstract

Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both cases showed near total effacement of the lymph node architecture by grade 1 FL (CD10+ and BCL2+) with accompanying in situ MCL component (CD5+ and cyclin D1+) surrounding neoplastic follicles. The diagnosis of composite FL and MCL was confirmed by detecting the t(14;18)(q32;q21) and t(11;14)(q13;q32) in the FL and MCL components, respectively. Immunoglobulin heavy chain fragment length analysis in both cases showed identical dominant monoclonal peaks in microdissected neoplastic lymphoid cells from FL and MCL components. These findings suggest a common clonal origin for the FL and MCL components in both cases.

摘要

复合性淋巴瘤伴滤泡性淋巴瘤（FL）和套细胞淋巴瘤（MCL）成分较为罕见，可能会带来较大的诊断挑战。我们报告了两例发生于淋巴结的复合性淋巴瘤伴 FL 和 MCL 成分。两例均表现为 1 级 FL（CD10+和 BCL2+）几乎完全破坏淋巴结结构，伴有原位 MCL 成分（CD5+和 cyclin D1+）围绕肿瘤性滤泡。通过分别在 FL 和 MCL 成分中检测到 t(14;18)(q32;q21) 和 t(11;14)(q13;q32)，确诊为复合性 FL 和 MCL。两例的免疫球蛋白重链片段长度分析均显示在 FL 和 MCL 成分的微切割肿瘤性淋巴样细胞中存在相同的优势单克隆峰。这些发现提示两例中的 FL 和 MCL 成分具有共同的克隆起源。