Martín-Ferrero M Á, Simón-Pérez C, Rodríguez-Mateos J I, García-Medrano B, Hernández-Ramajo R, Brotat-García M
Servicio de Cirugía ortopédica y Traumatología, Hospital Clínico Universitario de Valladolid, Valladolid, España.
Rev Esp Cir Ortop Traumatol. 2013 Nov-Dec;57(6):398-402. doi: 10.1016/j.recot.2013.07.005. Epub 2013 Sep 9.
The collagenase from Clostridium histolyticum is a new therapeutic option, and the first pharmacological one, in the treatment of Dupuytren's disease.
A prospective study was conducted on 35 patients with Dupuytren's disease. The clinical and functional variables, as well as patient satisfaction and drug safety were evaluated.
The functional and clinical results after its administration were good, with a rapid recovery, especially at the metacarpophalangeal (MCP) joint. The index finger contracture prior to MCP puncture was 64 degrees and after puncture it was 4 degrees. In the proximal interphalangeal (PIP) prior to puncture it was 83.3 degrees and after puncture it was 15 degrees; In the MCP/PIP prior to puncture it was 140 degrees, and after puncture it 25 degrees.
Collagenase from Clostridium histolyticum an alternative of treatment of Dupuytren's disease, mainly in the elderly. More research is required in order to clarify the rate of recurrence of the disease, the possible adverse reactions, and to compare the efficiency and permanence with other treatment options.
溶组织梭菌胶原酶是治疗掌腱膜挛缩症的一种新的治疗选择，也是第一种药物治疗方法。
对35例掌腱膜挛缩症患者进行了一项前瞻性研究。评估了临床和功能变量，以及患者满意度和药物安全性。
给药后的功能和临床效果良好，恢复迅速，尤其是在掌指关节处。掌指关节穿刺前食指挛缩为64度，穿刺后为4度。近端指间关节穿刺前为83.3度，穿刺后为15度；掌指关节/近端指间关节穿刺前为140度，穿刺后为25度。
溶组织梭菌胶原酶是治疗掌腱膜挛缩症的一种替代方法，主要适用于老年人。需要更多的研究来阐明该疾病的复发率、可能的不良反应，并与其他治疗选择比较疗效和持久性。
