Sánchez-Márquez J M, Sánchez Pérez-Grueso F J, Fernández-Baíllo N, Gil-Garay E, Antuña-Antuña S
Unidad de Raquis, Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz, Madrid, España.
Rev Esp Cir Ortop Traumatol. 2013 Sep-Oct;57(5):310-7. doi: 10.1016/j.recot.2013.07.001. Epub 2013 Sep 10.
To create an experimental structural scoliosis model in mice to evaluate the efficacy of shape-memory metals to gradually correct the deformity over time.
Experimental scoliosis was generated in 3 week-old mice by means of a suture between the left scapula and pelvis for 8 weeks. They were then randomised into two groups: a control group, in which the suture was cut, and another, in those that also had a Nitinol straight memory-wire implant fixed to the column. Serial X-rays were performed to determine the efficacy of the Nitinol in the correction of the scoliosis. In a second time, the histological changes at apical vertical body level and the adjacent discs were evaluated pre- and post-correction.
A mean 81.5° kyphoscoliosis was gradually induced. In the control group, after cutting the suture, an initial reduction in the deformity was observed, but later it remained stable throughout the time (54° at two weeks). In the Nitinol group, a gradual reduction was observed in the scoliosis angle value, to a mean of 8.7° at two weeks. The curvature of the apical vertebral body and adjacent discs were partially corrected after two weeks of correcting the deformity.
This scoliosis model has demonstrated the efficacy of a straight Nitinol wire fixed to the spinal column in the gradual correction of kyphoscoliosis and in the changes in its adjacent structures.
建立小鼠实验性结构性脊柱侧弯模型，以评估形状记忆金属随时间逐渐矫正畸形的效果。
通过在3周龄小鼠的左肩胛骨和骨盆之间缝合8周来诱导实验性脊柱侧弯。然后将它们随机分为两组：一组为对照组，切断缝合线；另一组在脊柱上固定镍钛诺直记忆丝植入物。进行系列X线检查以确定镍钛诺在矫正脊柱侧弯中的效果。其次，评估矫正前后椎体顶点和相邻椎间盘水平的组织学变化。
逐渐诱导出平均81.5°的脊柱后凸侧弯。在对照组中，切断缝合线后，观察到畸形最初有所减轻，但后来在整个观察期内保持稳定（两周时为54°）。在镍钛诺组中，观察到脊柱侧弯角度值逐渐减小，两周时平均为8.7°。在矫正畸形两周后，椎体顶点和相邻椎间盘的曲度得到部分矫正。
该脊柱侧弯模型已证明，固定在脊柱上的镍钛诺直丝在逐渐矫正脊柱后凸侧弯及其相邻结构变化方面具有疗效。
