Kinney E L, Wright R J
Reed Institute, Miami, Florida.
Angiology. 1990 Feb;41(2):112-7. doi: 10.1177/000331979004100204.
Two-dimensional echo cardiographic wall motion scores are potentially valuable prognostic indicators because of their association with subsequent mortality in patients with acute myocardial infarction. Because wall motion scores are relatively simple to obtain, they could come into widespread use. But wall motion scores have been found to have a low positive predictive accuracy in respect to one- or three-year survival and a low specificity in respect to pump failure. To clarify the value of wall motion scores in risk stratification the authors analyzed the ability of a wall motion index, in combination with other variables, to predict death within a year of acute myocardial infarction. Patients were 149 consecutive men with acute myocardial infarction. There were no exclusion criteria. By Cox regression, the variables most closely related to survival were the presence of a pericardial effusion, the age of the patient, alcoholism, and the E point septal separation. The wall motion index, by comparison, was only weakly related to survival and was therefore dropped from further analyses. The four variables most closely related to survival were then used to derive a predictive echocardiographic score. The score's negative predictive accuracy was 94%, although sensitivity and positive predictive accuracy were low. These data suggest that, even when applied nonselectively, the echocardiographic score, but not the wall motion index, appears to be an efficient way of characterizing the outcome of acute myocardial infarction, in that it reliably detects low-risk patients.
二维超声心动图壁运动评分是潜在有价值的预后指标,因为它们与急性心肌梗死患者随后的死亡率相关。由于壁运动评分相对容易获得,它们可能会得到广泛应用。但已发现壁运动评分在预测一年或三年生存率方面阳性预测准确性较低,在预测泵衰竭方面特异性较低。为了阐明壁运动评分在风险分层中的价值,作者分析了壁运动指数与其他变量相结合预测急性心肌梗死后一年内死亡的能力。患者为149例连续的急性心肌梗死男性。无排除标准。通过Cox回归分析,与生存最密切相关的变量是心包积液的存在、患者年龄、酗酒和E点室间隔分离。相比之下,壁运动指数与生存的相关性较弱,因此被排除在进一步分析之外。然后使用与生存最密切相关的四个变量得出一个预测性超声心动图评分。该评分的阴性预测准确性为94%,尽管敏感性和阳性预测准确性较低。这些数据表明,即使非选择性应用,超声心动图评分而非壁运动指数似乎是一种有效描述急性心肌梗死预后的方法,因为它能可靠地检测出低风险患者。