Baş Veysel Nijat, Ağladıoğlu Sebahat Yılmaz, Onder Aşan, Ozışık Pınar, Peltek Kendirci Havva Nur, Cetinkaya Semra, Aycan Zehra
Sami Ulus Women Health, Children's Education and Research Hospital, Clinics of Pediatric Endocrinology, Ankara, Turkey. E-mail:
J Clin Res Pediatr Endocrinol. 2013 Sep 10;5(3):202-5. doi: 10.4274/Jcrpe.993.
Cushing's disease is a condition in which hypercortisolism develops due to excessive hypophyseal adrenocorticotropic hormone production. It is rare in childhood. In this paper, we report the case of a 10-year-old male patient with hypophyseal microadenoma-related Cushing's disease who presented with obesity and was found to show poor height growth at follow-up. The diagnosis was confirmed with inferior petrosal sinus sampling, and the adenoma was successfully removed by transsphenoidal surgery. While adrenal axis suppression continued for approximately 1 year, clinical improvement was clearly observed after the third month following surgery. The findings in this patient demonstrate that decreased growth rate despite rapid weight gain in children can be early sign of Cushing's disease and emphasize the importance of monitoring of growth in obese children.
库欣病是一种由于垂体促肾上腺皮质激素分泌过多而导致皮质醇增多症的疾病。它在儿童期较为罕见。在本文中，我们报告了一例10岁男性垂体微腺瘤相关性库欣病患者，该患者表现为肥胖，随访时发现身高增长缓慢。经岩下窦采血确诊后，通过经蝶窦手术成功切除腺瘤。虽然肾上腺轴抑制持续了约1年，但术后第三个月后临床改善明显。该患者的发现表明，儿童体重快速增加但生长速率下降可能是库欣病的早期迹象，并强调了监测肥胖儿童生长情况的重要性。
