Clinics of Pediatric Endocrinology, Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Ankara, Turkey.
Eur J Pediatr. 2012 Apr;171(4):735-6. doi: 10.1007/s00431-011-1645-9. Epub 2011 Dec 28.
Iatrogenic Cushing syndrome may occur as an undesirable outcome of high-dose glucocorticoids treatments. This may also cause hypothalamus-hypophysis-adrenal axis suppression. While this situation may be caused more frequently with oral and topical glucocorticoid therapy, iatrogenic Cushing syndrome in childhood, caused by steroid-containing nasal drops, is a rare event. Hereby, we present a baby who developed iatrogenic Cushing syndrome induced by long-term use of steroid-containing nasal drops for choanal atresia. In conclusion, the serious side effects of the nasal drops should have been explained to the family, and their long-term use should have been refrained.
医源性库欣综合征可能是大剂量糖皮质激素治疗的不良后果。这也可能导致下丘脑-垂体-肾上腺轴抑制。虽然这种情况可能更频繁地发生在口服和局部糖皮质激素治疗中,但由含有类固醇的鼻腔滴剂引起的儿童医源性库欣综合征是一种罕见的事件。在此,我们介绍了一例婴儿,由于长期使用含有类固醇的鼻腔滴剂治疗后鼻孔闭锁而发生医源性库欣综合征。总之,应该向患儿家属解释鼻腔滴剂的严重副作用,并且应该避免长期使用。