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ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia.

作者信息

Zaliova M, Zimmermannova O, Dörge P, Eckert C, Möricke A, Zimmermann M, Stuchly J, Teigler-Schlegel A, Meissner B, Koehler R, Bartram C R, Karawajew L, Rhein P, Zuna J, Schrappe M, Cario G, Stanulla M

机构信息

1] Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany [2] CLIP-Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic [3] Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

CLIP-Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

出版信息

Leukemia. 2014 Jan;28(1):182-5. doi: 10.1038/leu.2013.282. Epub 2013 Sep 27.

DOI:10.1038/leu.2013.282
PMID:24072102
Abstract
摘要

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ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia.ERG缺失与CD2相关，并减弱IKZF1缺失在儿童急性淋巴细胞白血病中的负面影响。
Leukemia. 2014 Jan;28(1):182-5. doi: 10.1038/leu.2013.282. Epub 2013 Sep 27.
2
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.基因内 ERG 缺失是一种 B 细胞前体急性淋巴细胞白血病的致癌亚型标志物，尽管 IKZF1 缺失频繁，但预后良好。
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An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.基因内 ERG 缺失是一种 B 细胞前体急性淋巴细胞白血病的致癌亚型标志物，尽管 IKZF1 缺失频繁，但预后良好。
Leukemia. 2014 Jan;28(1):70-7. doi: 10.1038/leu.2013.277. Epub 2013 Sep 25.
2
IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol.IKZF1 缺失是根据 ALL-BFM 2000 方案治疗的儿童急性淋巴细胞白血病患者结局的独立预测因子。
Haematologica. 2013 Mar;98(3):428-32. doi: 10.3324/haematol.2011.056135. Epub 2012 Aug 8.
3
Biochem Genet. 2025 Jan 9. doi: 10.1007/s10528-024-11018-7.
4
Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition.胚系 ERG 杂合性缺失定义了一种具有血细胞减少和血液系统恶性肿瘤易感性的新综合征。
Blood. 2024 Oct 24;144(17):1765-1780. doi: 10.1182/blood.2024024607.
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Genetic alterations in lymphoblastic leukaemia.淋巴细胞白血病中的基因改变。
Med Genet. 2024 Mar 6;36(1):39-45. doi: 10.1515/medgen-2024-2007. eCollection 2024 Apr.
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is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemia.在患有B型急性淋巴细胞白血病的墨西哥儿科患者中，是不良预后的常见生物标志物。
Front Oncol. 2024 Apr 3;14:1337954. doi: 10.3389/fonc.2024.1337954. eCollection 2024.
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Promotion and maintenance of leukemia by ERG.ERG 促进和维持白血病。
Blood. 2011 Apr 7;117(14):3858-68. doi: 10.1182/blood-2010-11-320515. Epub 2011 Feb 14.
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Biology, risk stratification, and therapy of pediatric acute leukemias: an update.儿科急性白血病的生物学、风险分层和治疗：更新。
J Clin Oncol. 2011 Feb 10;29(5):551-65. doi: 10.1200/JCO.2010.30.7405. Epub 2011 Jan 10.
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The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function.NOTCH1 受体突变对接受 ALL-BFM 2000 方案治疗的 T-ALL 患者长期预后的有利影响，可以与 FBXW7 功能丧失相分离。
Leukemia. 2010 Dec;24(12):2005-13. doi: 10.1038/leu.2010.203. Epub 2010 Oct 14.
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Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.基于基因表达谱鉴定儿童高危 B 前体细胞急性淋巴细胞白血病中的新型聚类群：与全基因组 DNA 拷贝数改变、临床特征和预后的相关性。
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