Tso Winnie Wan-Yee, Yung Ada Wing-Yan, Lau Hin-Yue, Chan Godfrey Chi-Fung
Departments of *Paediatrics and Adolescent Medicine †Diagnostic Radiology, Hong Kong University, Queen Mary Hospital, Hong Kong, China.
J Pediatr Hematol Oncol. 2014 Oct;36(7):e443-7. doi: 10.1097/MPH.0000000000000014.
Basal ganglia germinomas (BGG) are often associated with delayed diagnosis because of their nonspecific clinical presentation and subtle abnormalities on initial neuroimaging. Despite excellent survival, the prognostic indicators still remained unclear. From our case series, we demonstrated that the MRI classification scheme devised by Phi and colleagues is useful in predicting neurological and cognitive outcomes for patients with unilateral BGG. Subtle lesions with faint or no contrast enhancement are associated with early cerebral atrophy with progressive neurological deficits and poor cognitive outcomes. BGG along with bilateral involvement, regardless of the types of lesion, are also associated with poor neurological and cognitive outcomes.
基底节生殖细胞瘤（BGG）由于其非特异性临床表现和初始神经影像学检查的细微异常，常导致诊断延迟。尽管生存率很高，但预后指标仍不明确。从我们的病例系列来看，我们证明了Phi及其同事设计的MRI分类方案有助于预测单侧BGG患者的神经和认知结局。强化微弱或无强化的细微病变与早期脑萎缩、进行性神经功能缺损及不良认知结局相关。无论病变类型如何，双侧受累的BGG也与不良神经和认知结局相关。
