荷包牡丹碱拮抗多巴胺及其类似物肾上腺素能抑制作用的能力。
Bulbocapnine's ability to antagonize the adrenergic inhibitory action of dopamine and analogs.
作者信息
Ilhan M, Long J P, Cannon J G
出版信息
Eur J Pharmacol. 1975 Aug;33(1):13-8. doi: 10.1016/0014-2999(75)90132-6.
PMID:240727
Abstract
Dopamine in the presence of cocaine, 5,6-dihydroxy-2-dimethylaminotetralin (M-7), apomorphine and N,N-dimethyldopamine produced dose dependent inhibition on the heart rate increase due to stimulation of the right cardioaccelerator postganglionic nerves. Inhibitory actions of these compounds were antagonized by bulbocapnine. Also bulbocapnine antagonized the blood pressure increase due to N,N-dimethyldopamine but did not antagonize the pressor response of dopamine.
摘要
在可卡因、5,6 - 二羟基 - 2 - 二甲基氨基四氢萘（M - 7）、阿扑吗啡和N,N - 二甲基多巴胺存在的情况下，多巴胺对因刺激右侧心加速神经节后神经而导致的心率增加产生剂量依赖性抑制作用。这些化合物的抑制作用可被荷包牡丹碱拮抗。此外，荷包牡丹碱可拮抗N,N - 二甲基多巴胺引起的血压升高，但不能拮抗多巴胺的升压反应。
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