• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance.

作者信息

Varettoni Marzia, Zibellini Silvia, Arcaini Luca, Boveri Emanuela, Rattotti Sara, Pascutto Cristiana, Mangiacavalli Silvia, Gotti Manuel, Pochintesta Lara, Paulli Marco, Cazzola Mario

机构信息

Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy.

出版信息

Blood. 2013 Sep 26;122(13):2284-5. doi: 10.1182/blood-2013-07-513366.

DOI:10.1182/blood-2013-07-513366
PMID:24072850
Abstract
摘要

相似文献

1
MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance.MYD88（L265P）突变是意义未明的IgM单克隆丙种球蛋白病患者病情进展的独立危险因素。
Blood. 2013 Sep 26;122(13):2284-5. doi: 10.1182/blood-2013-07-513366.
2
Prevalence and prognosis implication of MYD88 L265P mutation in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia.MYD88 L265P突变在意义未明的IgM单克隆丙种球蛋白病和冒烟型华氏巨球蛋白血症中的患病率及预后意义
Br J Haematol. 2017 Dec;179(5):849-851. doi: 10.1111/bjh.14266. Epub 2016 Sep 8.
3
Detection of MYD88 L265P and WHIM-like CXCR4 mutation in patients with IgM monoclonal gammopathy related disease.IgM单克隆丙种球蛋白病相关疾病患者中MYD88 L265P和WHIM样CXCR4突变的检测
Ann Hematol. 2017 Jun;96(6):971-976. doi: 10.1007/s00277-017-2968-z. Epub 2017 Mar 9.
4
Detection of MYD88 L265P in peripheral blood of patients with Waldenström's Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.检测 Waldenström 巨球蛋白血症和意义未明的单克隆免疫球蛋白血症患者外周血中的 MYD88 L265P。
Leukemia. 2014 Aug;28(8):1698-704. doi: 10.1038/leu.2014.65. Epub 2014 Feb 10.
5
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.用常规和定量等位基因特异性聚合酶链反应检测 Waldenström 巨球蛋白血症、免疫球蛋白 M 单克隆丙种球蛋白病和其他 B 细胞淋巴增殖性疾病中的 MYD88 L265P。
Blood. 2013 Mar 14;121(11):2051-8. doi: 10.1182/blood-2012-09-454355. Epub 2013 Jan 15.
6
The MYD88 conundrum in IgM monoclonal gammopathy of undetermined significance.意义未明的IgM单克隆丙种球蛋白病中的MYD88难题
Br J Haematol. 2019 Nov;187(4):413-415. doi: 10.1111/bjh.16085. Epub 2019 Jul 12.
7
A risk-stratification model based on the initial concentration of the serum monoclonal protein and MYD88 mutation status identifies a subset of patients with IgM monoclonal gammopathy of undetermined significance at high risk of progression to Waldenström macroglobulinaemia or other lymphoproliferative disorders.一种基于血清单克隆蛋白初始浓度和 MYD88 突变状态的风险分层模型，可确定一部分免疫球蛋白 M 单克隆丙种球蛋白血症患者具有较高进展为华氏巨球蛋白血症或其他淋巴增殖性疾病的风险。
Br J Haematol. 2019 Nov;187(4):441-446. doi: 10.1111/bjh.16086. Epub 2019 Jul 5.
8
Pattern of somatic mutations in patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance.瓦尔登斯特伦巨球蛋白血症或意义未明的单克隆免疫球蛋白血症患者的体细胞突变模式。
Haematologica. 2017 Dec;102(12):2077-2085. doi: 10.3324/haematol.2017.172718. Epub 2017 Oct 5.
9
B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS.B 细胞特异性 Myd88 L252P 表达导致类似于 IgM MGUS 的前恶性浆细胞病。
Front Immunol. 2020 Dec 1;11:602868. doi: 10.3389/fimmu.2020.602868. eCollection 2020.
10
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms.华氏巨球蛋白血症和相关淋巴肿瘤中 MYD88（L265P）体细胞突变的流行率及临床意义。
Blood. 2013 Mar 28;121(13):2522-8. doi: 10.1182/blood-2012-09-457101. Epub 2013 Jan 25.

引用本文的文献

1
Targeting BCL2 in Waldenström macroglobulinemia: from biology to treatment management.靶向治疗华氏巨球蛋白血症中的BCL2：从生物学机制到治疗管理
Front Oncol. 2025 Apr 22;15:1564869. doi: 10.3389/fonc.2025.1564869. eCollection 2025.
2
Waldenström Macroglobulinemia - A State-of-the-Art Review: Part 1: Epidemiology, Pathogenesis, Clinicopathologic Characteristics, Differential Diagnosis, Risk Stratification, and Clinical Problems.华氏巨球蛋白血症——最新综述：第1部分：流行病学、发病机制、临床病理特征、鉴别诊断、风险分层及临床问题
Mediterr J Hematol Infect Dis. 2024 Jul 1;16(1):e2024061. doi: 10.4084/MJHID.2024.061. eCollection 2024.
3
Good clinical response following Ibrutinib treatment of a rare case of lymphoplasmacytic lymphoma secreting IgA kappa paraprotein: A case report.
依鲁替尼治疗一例罕见的分泌IgA κ副蛋白的淋巴浆细胞淋巴瘤后的良好临床反应：病例报告
Oncol Lett. 2024 May 28;28(2):338. doi: 10.3892/ol.2024.14471. eCollection 2024 Aug.
4
MYD88 L265P Mutation Detection by ddPCR: Recommendations for Screening and Minimal Residual Disease Monitoring : ddPCR for Highly Sensitive Detection of MYD88 L265P Mutation.采用 ddPCR 技术检测 MYD88 L265P 突变：筛查和微小残留病监测的推荐方法：ddPCR 技术用于高度敏感检测 MYD88 L265P 突变。
Methods Mol Biol. 2023;2621:57-72. doi: 10.1007/978-1-0716-2950-5_5.
5
An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas.衰老/自身免疫 B 细胞程序定义了结外淋巴瘤的早期转化。
Cancer Discov. 2023 Jan 9;13(1):216-243. doi: 10.1158/2159-8290.CD-22-0561.
6
Differential Diagnosis of Waldenström's Macroglobulinemia and Early Management: Perspectives from Clinical Practice.华氏巨球蛋白血症的鉴别诊断与早期管理：临床实践视角
Blood Lymphat Cancer. 2022 Aug 18;12:107-117. doi: 10.2147/BLCTT.S259860. eCollection 2022.
7
Mutations: Transforming the Landscape of IgM Monoclonal Gammopathies.突变：改变 IgM 单克隆丙种球蛋白血症的格局。
Int J Mol Sci. 2022 May 16;23(10):5570. doi: 10.3390/ijms23105570.
8
Nucleic Acid Biomarkers in Waldenström Macroglobulinemia and IgM-MGUS: Current Insights and Clinical Relevance.华氏巨球蛋白血症和IgM单克隆丙种球蛋白病中的核酸生物标志物：当前见解与临床相关性
Diagnostics (Basel). 2022 Apr 12;12(4):969. doi: 10.3390/diagnostics12040969.
9
Genomic landscape of Waldenström's macroglobulinemia.华氏巨球蛋白血症的基因组图谱
Hemasphere. 2019 Jun 30;3(Suppl). doi: 10.1097/HS9.0000000000000228. eCollection 2019 Jun.
10
IgM-MM is predominantly a pre-germinal center disorder and has a distinct genomic and transcriptomic signature from WM.IgM-MM 主要是生发中心前疾病，其基因组和转录组特征与 WM 明显不同。
Blood. 2021 Nov 18;138(20):1980-1985. doi: 10.1182/blood.2021011452.