糖尿病预防计划的转化研究系统评价。
A systematic review of the translational research on the Diabetes Prevention Program.
作者信息
Whittemore Robin
机构信息
Yale School of Nursing, 100 Church Street South, New Haven, CT 06536 USA.
出版信息
Transl Behav Med. 2011 Sep;1(3):480-91. doi: 10.1007/s13142-011-0062-y.
Abstract
International clinical trials have demonstrated compelling evidence on the prevention or delay of type 2 diabetes (T2D) by lifestyle change programs. Numerous studies have translated the Diabetes Prevention Program (DPP) protocol to "real-world" settings. The purpose of this paper is to review the translational research of the DPP protocol in adults at-risk for T2D. This study is a systematic review based on the guidelines from the Cochrane Handbook for Systematic Reviews. There were 16 studies that translated the DPP protocol in four distinct settings: (a) hospital outpatient, (b) primary care, (c) community, and (d) work and church. Settings varied considerably in terms of reach, efficacy, adoption, implementation, and maintenance. There were strengths and limitations to each setting. Better understanding of program adaptation and mediators and moderators to program efficacy are indicated. Future research also needs to continue to explore mechanisms to improve access and long-term outcomes.
摘要
国际临床试验已经证明，生活方式改变计划在预防或延缓2型糖尿病（T2D）方面有令人信服的证据。许多研究已将糖尿病预防计划（DPP）方案应用于“现实世界”环境。本文的目的是回顾DPP方案在有T2D风险的成年人中的转化研究。本研究是一项基于Cochrane系统评价手册指南的系统评价。有16项研究在四种不同环境中应用了DPP方案：（a）医院门诊，（b）初级保健，（c）社区，以及（d）工作场所和教会。这些环境在覆盖范围、疗效、采用率、实施情况和维持方面差异很大。每种环境都有优点和局限性。表明需要更好地理解方案调整以及影响方案疗效的中介因素和调节因素。未来的研究还需要继续探索改善可及性和长期结果的机制。
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