阿尔茨海默病型痴呆弥漫性斑块中β淀粉样蛋白的免疫电子显微镜定位
Immunoelectron microscopic localization of amyloid beta protein in the diffuse plaques of Alzheimer-type dementia.
作者信息
Yamaguchi H, Nakazato Y, Hirai S, Shoji M
机构信息
College of Medical Care and Technology, Gunma University, Japan.
出版信息
Brain Res. 1990 Feb 5;508(2):320-4. doi: 10.1016/0006-8993(90)90416-9.
We examined the ultrastructural localization of beta protein in diffuse plaques of Alzheimer brain by indirect immunoperoxidase technique. Intense immunoreaction products, scattered sporadically in the diffuse plaques, were located on small bundles of several amyloid fibrils and/or amorphous materials between amyloid-related cell processes (ARCP). Deposits of beta protein were also seen on parts of the cell membrane of ARCP, suggesting the importance of ARCP in plaque amyloid deposits.
我们采用间接免疫过氧化物酶技术，研究了β蛋白在阿尔茨海默病脑弥漫性斑块中的超微结构定位。强烈的免疫反应产物散在分布于弥漫性斑块中，位于几根淀粉样纤维的小束和/或淀粉样相关细胞突起（ARCP）之间的无定形物质上。在ARCP细胞膜的部分区域也可见β蛋白沉积，提示ARCP在斑块淀粉样沉积中具有重要作用。
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