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髓源性抑制细胞、年龄与癌症。

Myeloid-derived suppressor cells, age and cancer.

作者信息

Bowdish Dawn Me

机构信息

McMaster Immunology Research Centre & MG DeGroote Institute for Infectious Disease Research; McMaster University; West Hamilton, ON Canada.

出版信息

Oncoimmunology. 2013 Jul 1;2(7):e24754. doi: 10.4161/onci.24754. Epub 2013 Apr 30.

DOI:10.4161/onci.24754
PMID:24073368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3782016/
Abstract

We have recently discovered that the levels of circulating myeloid-derived suppressor cells, which are associated with an impaired T-cell proliferation and produce high amounts of reactive oxygen species, increase with age and are elevated in individuals in remission from cancer. Herein, potential mechanisms underpinning these observations are discussed.

摘要

我们最近发现，循环髓源性抑制细胞的水平会随着年龄增长而升高，并且在癌症缓解期的个体中也会升高。这些细胞与T细胞增殖受损有关，并会产生大量活性氧。本文将讨论这些观察结果背后的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee89/3782016/862deabf35f0/onci-2-e24754-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee89/3782016/862deabf35f0/onci-2-e24754-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee89/3782016/862deabf35f0/onci-2-e24754-g1.jpg

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2
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Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.
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Contribution of Aging, Obesity, and Microbiota on Tumor Immunotherapy Efficacy and Toxicity.衰老、肥胖和微生物组对肿瘤免疫治疗疗效和毒性的影响。
Int J Mol Sci. 2019 Jul 23;20(14):3586. doi: 10.3390/ijms20143586.
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