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胰腺癌相关星状细胞：降低肿瘤微环境中免疫抑制作用的可行靶点。

Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment.

作者信息

Mace Thomas A, Bloomston Mark, Lesinski Gregory B

机构信息

Division of Medical Oncology; Department of Internal Medicine; The Ohio State University; Columbus, OH USA.

出版信息

Oncoimmunology. 2013 Jul 1;2(7):e24891. doi: 10.4161/onci.24891. Epub 2013 May 7.

DOI:10.4161/onci.24891
PMID:24073373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3782129/
Abstract

Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the efficacy of immunotherapeutic regimens against pancreatic cancer.

摘要

胰腺癌相关的星状细胞分泌可溶性因子，如白细胞介素-6（IL-6），其通过信号转导和转录激活因子3（STAT3）依赖性机制促进髓源性抑制细胞的积累。因此，靶向肿瘤基质内的IL-6/JAK/STAT3信号轴成分可以抑制局部免疫抑制，并提高针对胰腺癌的免疫治疗方案的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b828/3782129/8e1919358599/onci-2-e24891-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b828/3782129/8e1919358599/onci-2-e24891-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b828/3782129/8e1919358599/onci-2-e24891-g1.jpg

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