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Complete remission of brain metastases of ovarian cancer following high-dose carboplatin: a case report and pharmacokinetic study.

作者信息

Vlasveld L T, Beynen J H, Boogerd W, Ten Bokkel Huinink W W, Rodenhuis S

机构信息

Clinical Research Unit, Netherlands Cancer Institute, Amsterdam.

出版信息

Cancer Chemother Pharmacol. 1990;25(5):382-3. doi: 10.1007/BF00686244.

DOI:10.1007/BF00686244
PMID:2407368
Abstract

Brain metastases developed in a 40-year-old woman with relapsed ovarian cancer 2 years after cisplatin-based combination chemotherapy. After a single dose of 800 mg/m2 carboplatin, complete remission of the brain metastases occurred. A pharmacokinetic study during the second course revealed low levels of carboplatin in the cerebrospinal fluid.

摘要

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J Clin Oncol. 1990 Aug;8(8):1335-41. doi: 10.1200/JCO.1990.8.8.1335.
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[Evaluation of the renal function in patients with ovarian carcinoma subjected to polychemotherapy including cisplatin or carboplatin].[对接受包括顺铂或卡铂在内的多药化疗的卵巢癌患者的肾功能评估]
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本文引用的文献

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Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients.他莫昔芬及其代谢产物在乳腺癌患者脑组织和脑转移灶中的分布。
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6
Comparative distribution and excretion of carboplatin and cisplatin in mice.卡铂和顺铂在小鼠体内的分布及排泄比较
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7
Current status of chemotherapy for ovarian carcinoma.卵巢癌化疗的现状
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8
Central nervous system metastases in epithelial ovarian carcinoma.
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Cancer. 1987 Nov 15;60(10):2559-62. doi: 10.1002/1097-0142(19871115)60:10<2559::aid-cncr2820601035>3.0.co;2-7.
10
Analysis of platinum in biological materials by flameless atomic absorption spectrophotometry.用无火焰原子吸收分光光度法分析生物材料中的铂。
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