Dauplat J, Nieberg R K, Hacker N F
Department of Obstetrics and Gynecology, UCLA School of Medicine.
Cancer. 1987 Nov 15;60(10):2559-62. doi: 10.1002/1097-0142(19871115)60:10<2559::aid-cncr2820601035>3.0.co;2-7.
Five new cases of central nervous system (CNS) metastases from epithelial ovarian cancer are described. They are discovered among 255 patients treated at University of California, Los Angeles (UCLA) Medical Center, giving an incidence of CNS metastases of 1.96%. All five patients had intraparenchymal brain metastases. It seems likely that the incidence of CNS involvement is increasing in this disease, consonant with improvement of local tumor control and prolonged overall survival. The median duration from the diagnosis of ovarian cancer to the diagnosis of CNS metastases was 25 months (range, 10-126 months). Median survival after diagnosis was 1.3 months (range, 1-10 months). Therapeutic options are discussed, as are possible mechanisms for the occurrence of these metastases.
本文描述了5例上皮性卵巢癌中枢神经系统（CNS）转移的新病例。这些病例是在加利福尼亚大学洛杉矶分校（UCLA）医学中心接受治疗的255例患者中发现的，CNS转移的发生率为1.96%。所有5例患者均有脑实质内转移。这种疾病中CNS受累的发生率似乎在增加，这与局部肿瘤控制的改善和总体生存期的延长相一致。从卵巢癌诊断到CNS转移诊断的中位时间为25个月（范围10 - 126个月）。诊断后的中位生存期为1.3个月（范围1 - 10个月）。文中讨论了治疗选择以及这些转移发生的可能机制。
