St Anna Children's Hospital, Stem cell transplantation, Medical University of Vienna, Vienna, Austria.
Expert Rev Anti Infect Ther. 2013 Oct;11(10):1017-28. doi: 10.1586/14787210.2013.836964. Epub 2013 Sep 27.
In immunocompromised patients, human adenovirus (HAdV) infections can cause life-threatening multiorgan disease. This review summarizes the incidence and risk factors of invasive human adenovirus infections in immunocompromised patients as well as the recently developed standards for diagnostic methods and strategies according to the predominant risk factors in adults and children. Recommendations for preemptive and therapeutic treatment strategies and the outcome in different risk groups are presented. Novel therapeutic approaches including CMX001, a new orally bioavailable lipid conjugate of cidofovir and the transfer of adenovirus-specific donor T cells in the context of allogeneic stem cell transplantation are discussed.
在免疫功能低下的患者中，人类腺病毒（HAdV）感染可导致危及生命的多器官疾病。本综述总结了免疫功能低下患者侵袭性人类腺病毒感染的发生率和危险因素，以及根据成人和儿童的主要危险因素制定的最新诊断方法和策略标准。本文还介绍了针对不同风险群体的预防性和治疗性治疗策略及结果。本文还讨论了包括 CMX001 在内的新型治疗方法，CMX001 是一种新的口服生物可利用的西多福韦脂质缀合物，以及同种异体干细胞移植背景下腺病毒特异性供体 T 细胞的转移。
