Qashqari Fadi S I
Department of Microbiology, College of Medicine, Umm Al-Qura University, Makkah 24381, Saudi Arabia.
Children (Basel). 2022 Sep 6;9(9):1356. doi: 10.3390/children9091356.
Human mastadenovirus (HAdV) is a non-enveloped icosahedral virus with double-stranded DNA genomes. The mortality rate of HAdV infections can reach 35.5%, while gastroenteritis HAdV infections, HAdV pneumonia, and disseminated disease tend to show a worse outcome, with rates ranging from 44.2% to 50%. In addition, HAdV can cause infections at any age but most commonly in the pediatric population, especially in young children and infants. Therefore, this review aims to assess the current status of HAdV infections among children in the Arab World, particularly in the Middle East and North Africa. Web of Science, Scopus, PubMed, EMBASE, and Google Scholar databases for publications in English were searched up to July 2022 for relevant articles. The literature search yielded a total of 21 studies, which were included in this review. Studies reporting HAdV infections in children were conducted in 17 out of the 22 countries. The average prevalence rate of HAdV infections in children was 12.7%, with average prevalence rates of 12.82% and 12.58% in the Middle East and North African countries, respectively. The highest prevalence rate (28.3%) was reported in Egypt, whereas the lowest prevalence (1.5%) was reported in Sudan. The included studies presented children with signs and symptoms of gastroenteritis, acute respiratory infection, acute diarrhea, and acute hemorrhagic conjunctivitis. In conclusion, the average prevalence rate of HAdV infections in children was 12.7%, with average prevalence rates of 12.82% and 12.58% in the Middle East and North African countries, respectively. Finding the precise prevalence rate of this virus is crucial because it will guide future planning for effective disease control and the selection of particular treatment options during epidemics and special seasons.
人腺病毒（HAdV）是一种无包膜的二十面体病毒，具有双链DNA基因组。HAdV感染的死亡率可达35.5%，而腺病毒胃肠炎感染、腺病毒肺炎和播散性疾病往往预后更差，死亡率在44.2%至50%之间。此外，HAdV可在任何年龄引起感染，但最常见于儿童群体，尤其是幼儿和婴儿。因此，本综述旨在评估阿拉伯世界儿童中HAdV感染的现状，特别是中东和北非地区。截至2022年7月，检索了Web of Science、Scopus、PubMed、EMBASE和谷歌学术数据库中以英文发表的相关文章。文献检索共获得21项研究，纳入了本综述。在22个国家中的17个国家进行了关于儿童HAdV感染的研究。儿童中HAdV感染的平均患病率为12.7%，中东国家和北非国家的平均患病率分别为12.82%和12.58%。埃及报告的患病率最高（28.3%），而苏丹报告的患病率最低（1.5%）。纳入的研究呈现了患有胃肠炎、急性呼吸道感染、急性腹泻和急性出血性结膜炎体征和症状的儿童。总之，儿童中HAdV感染的平均患病率为12.7%，中东国家和北非国家的平均患病率分别为12.82%和12.58%。确定这种病毒的确切患病率至关重要，因为它将指导未来有效疾病控制的规划以及在疫情和特殊季节选择特定的治疗方案。
