Center for Health Outcomes Research, United BioSource Corporation, Bethesda, MD, USA.
Int J Clin Pract. 2013 Oct;67(10):1015-33. doi: 10.1111/ijcp.12164.
Studies on the burden and comorbidities associated with urgency urinary incontinence (UUI) are difficult to compare, partly because of the evolution of definitions for lower urinary tract symptoms and the various instruments used to assess health-related quality of life (HRQL). This article summarises published evidence on comorbidities and the personal burden associated specifically with UUI to provide clinicians with a clear perspective on the impact of UUI on patients.
A PubMed search was conducted using the terms: (urgency urinary incontinence OR urge incontinence OR mixed incontinence OR overactive bladder) AND (burden OR quality of life OR well-being OR depression OR mental health OR sexual health OR comorbid), with limits for English-language articles published between 1991 and 2011.
Of 1364 identified articles, data from 70 retained articles indicate that UUI is a bothersome condition that has a marked negative impact on HRQL, with the severity of UUI a predictor of HRQL. UUI is significantly associated with falls in elderly individuals, depression, urinary tract infections, increased body mass index, diabetes and deaths. The burden of UUI appears to be greater than that of stress urinary incontinence or overactive bladder symptoms without UUI. UUI adversely impacts physical and mental health, sexual function and work productivity.
UUI is associated with numerous comorbid conditions and inflicts a substantial personal burden on many aspects of patients' lives. Healthcare providers should discuss UUI with patients and be aware of the impact of UUI and its associated comorbidities on patients' lives.
与急迫性尿失禁（UUI）相关的负担和合并症的研究较难进行比较，部分原因是下尿路症状的定义不断演变，以及评估健康相关生活质量（HRQL）的各种工具也在不断变化。本文总结了有关合并症和与 UUI 相关的个人负担的已发表证据，为临床医生提供了 UUI 对患者影响的清晰视角。
使用以下术语在 PubMed 上进行了搜索：（急迫性尿失禁或急迫性尿失禁或混合性尿失禁或膀胱过度活动症）和（负担或生活质量或健康幸福感或抑郁或心理健康或性健康或合并症），并限制了 1991 年至 2011 年间发表的英文文章。
在 1364 篇确定的文章中，有 70 篇保留文章的数据表明，UUI 是一种令人烦恼的疾病，对 HRQL 有明显的负面影响，UUI 的严重程度是 HRQL 的预测指标。UUI 与老年人跌倒、抑郁、尿路感染、体重指数增加、糖尿病和死亡显著相关。UUI 的负担似乎大于无 UUI 的压力性尿失禁或膀胱过度活动症症状的负担。UUI 对身心健康、性功能和工作效率产生不利影响。
UUI 与许多合并症相关，并对患者生活的许多方面造成重大的个人负担。医疗保健提供者应与患者讨论 UUI 问题，并意识到 UUI 及其相关合并症对患者生活的影响。
