Haddy F J, Scott J B
Fed Proc. 1975 Oct;34(11):2006-11.
The old and recent literature bearing on the role of metabolic factors in exercise hyperemia has been reviewed. Two general conclusions have gradually emerged over the years. First, no one factor is by itself a sufficient explanation for the hyperemia. Second, the contributions of the various factors appear to change with time of exercise. While additional temporal studies are needed to firmly establish more specific conclusions, those now available suggest that factors related to skeletal muscle cell depolarization initiate the hyperemia while factors related to oxygen consumption in excess of oxygen delivery contribute more to the maintenance of the hyperemia. For example, the potassium that leaves the skeletal muscle cell on depolarization appears to contribute more to the initiation of the hyperemia than to its maintenance. Hydrogen, on the other hand, appears to have little to do with initiation but may contribute to maintenance, at least with grades of exercise that reduce cellular oxygen tension. The picture that emerges from the review seems to be one of multiple factors acting in concert with a changing temporal pattern.
有关代谢因素在运动性充血中作用的新旧文献已被综述。多年来逐渐得出了两个一般性结论。首先，没有一个因素本身能充分解释充血现象。其次，各种因素的作用似乎会随运动时间而变化。虽然需要更多的时间研究来坚定地得出更具体的结论，但目前可得的研究表明，与骨骼肌细胞去极化相关的因素引发充血，而与氧耗超过氧输送相关的因素对充血的维持作用更大。例如，去极化时离开骨骼肌细胞的钾似乎对充血的引发作用比对其维持作用更大。另一方面，氢似乎与引发作用关系不大，但可能有助于维持充血，至少在降低细胞氧张力的运动强度下是如此。综述中呈现的情况似乎是多种因素协同作用且时间模式不断变化。
