血管外皮细胞瘤侵袭的分子机制。
The molecular mechanisms on glomangiopericytoma invasion.
机构信息
Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.
出版信息
Orphanet J Rare Dis. 2013 Sep 29;8:152. doi: 10.1186/1750-1172-8-152.
PURPOSE
To observed the imaging and pathological features of the glomangiopericytoma.
EXPERIMENTAL DESIGN
In this paper we report a typical case of glomangiopericytoma arising in the skull base area and summarize the clinical manifestations, imaging and pathological features of such diseases.
RESULTS
Immunohistochemical staining confirmed the tumor cells were strongly positive to Vim, SMA, MSA and negative to CD31, CD34. Partial cells were positive to FVIII. The imaging can't confirm the diagnosis but indicate the the tumor has intact envelope.The cells in the tumor envelope is positive to Vim and negative SMA and FVIII. These findings were compatible with glomangiopericytoma and the cells in the tumor envelope is not glomangiopericytoma cells.
CONCLUSION
In view of the clinical and pathological features of the glomangiopericytoma, we believe that the surgery is the best treatment so far and the tumor can be resected completely. The above results can be preliminary reason to explain the low recurrence of such diseases.
目的
观察血管外皮细胞瘤的影像学和病理学特征。
实验设计
本文报告了一例发生于颅底的典型血管外皮细胞瘤，并总结了此类疾病的临床表现、影像学和病理学特征。
结果
免疫组化染色证实肿瘤细胞强阳性表达 Vim、SMA、MSA，阴性表达 CD31、CD34，部分细胞阳性表达 FVIII。影像学不能明确诊断，但提示肿瘤包膜完整。肿瘤包膜内的细胞阳性表达 Vim，阴性表达 SMA 和 FVIII。这些发现符合血管外皮细胞瘤，肿瘤包膜内的细胞不是血管外皮细胞瘤细胞。
结论
鉴于血管外皮细胞瘤的临床和病理学特征，我们认为手术是目前最好的治疗方法，可以完全切除肿瘤。上述结果可以初步解释该疾病低复发率的原因。
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