Furihata M, Takeuchi T, Iwata J, Sonobe H, Ohtsuki Y, Wakatsuki A, Morioka N, Sagara Y
Department of Pathology II, Kochi Medical School, Nankoku, Japan.
Pathol Int. 1998 Dec;48(12):967-73. doi: 10.1111/j.1440-1827.1998.tb03868.x.
Primary ovarian angiosarcoma is extremely rare. Only 16 cases have histologically been reported to date in the literature. A case of angiosarcoma arising in the right ovary of a 46-year-old female is presented. Grossly, the resected right ovary was completely replaced by a solid tumor mass, which revealed multiple necrotic and/or hemorrhagic foci. This case revealed the typical histological features of angiosarcoma with sinusoidal and solid patterns of anaplastic tumor cells. Immunohistochemically, tumor cells were strongly and diffusely positive for CD31 and CD34, in particular, along the cytoplasmic membrane of the tumor cells. Ultrastructurally, tumor cells possessed the intermediate junctions between tumor cells, discontinuous basal laminae attached to the irregularly shaped blood vessels and occasional cytoplasmic pinocytotic vesicles. These findings confirmed the case as being one of angiosarcoma of the ovary. The patient died 9 months after surgery as a result of developed multifocal brain metastases. A total of 17 cases reported as primary ovarian angiosarcoma, including this presented case, are clinicopathologically reviewed.
原发性卵巢血管肉瘤极为罕见。迄今为止，文献中经组织学证实报道的仅有16例。本文报告1例发生于46岁女性右侧卵巢的血管肉瘤。大体上，切除的右侧卵巢完全被实性肿瘤块取代，可见多个坏死和/或出血灶。该病例显示了血管肉瘤典型的组织学特征，即间变性肿瘤细胞呈窦状和实性结构。免疫组化显示，肿瘤细胞CD31和CD34呈强阳性且弥漫性分布，尤其是沿肿瘤细胞的细胞膜。超微结构上，肿瘤细胞间有中间连接，不规则形血管附着有不连续的基膜，并有散在的胞质吞饮小泡。这些发现证实该病例为卵巢血管肉瘤。患者术后9个月因多发脑转移死亡。包括本病例在内，共17例报告为原发性卵巢血管肉瘤的病例进行了临床病理分析。
