MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.
Clin Exp Allergy. 2013 Oct;43(10):1180-8. doi: 10.1111/cea.12172.
It has been suggested that maternal vitamin D status in pregnancy influences the risk of asthma and atopy in the offspring. The epidemiological evidence to support these claims is conflicting and may reflect chance findings and differences in how vitamin D was assessed.
To examine the association between blood total maternal 25-hydroxy vitamin D (25(OH)D) concentrations in pregnancy and offspring asthma, atopy and lung function in the largest birth cohort study to date.
Participants were largely of white European origin and resident in the South West of England. We examined the associations of maternal 25(OH)D concentrations in pregnancy with the following outcomes in the offspring: wheeze, asthma, atopy, eczema, hayfever, at mean age 7.5 years (n = 3652-4696 depending on outcome), IgE at 7 years (n = 2915) and lung function and bronchial responsiveness at mean age 8.7 years (n = 3728-3784).
Sixty-eight per cent of mothers had sufficient (> 50 nmol/L) concentrations of 25(OH)D, 27% were insufficient (27.5-49.99 nmol/L) and 5% were deficient (< 27.5 nmol/L). There was no evidence to suggest that maternal 25(OH)D concentration in pregnancy was associated with any respiratory or atopic outcome in the offspring. These findings remained after adjustment for season of measurement and for potential confounders. There was also no evidence that these relationships followed a non-linear form and no evidence that either deficient or high concentrations of maternal 25(OH)D were associated with atopic or respiratory outcomes.
We found no evidence that maternal blood 25(OH)D concentration in pregnancy is associated with childhood atopic or respiratory outcomes.
有研究表明，孕妇的维生素 D 状况会影响后代患哮喘和过敏的风险。支持这些说法的流行病学证据存在冲突，这可能反映了偶然发现和评估维生素 D 的方法的差异。
在迄今为止最大的出生队列研究中，检查孕妇血液总 25-羟维生素 D（25（OH）D）浓度与后代哮喘、过敏和肺功能之间的关系。
参与者主要为白种欧洲人，居住在英格兰西南部。我们检查了孕妇 25（OH）D 浓度与以下后代结果之间的关联：在 7.5 岁时出现喘息、哮喘、过敏、特应性皮炎、花粉症、7 岁时的 IgE（n=2915）以及平均年龄为 8.7 岁时的肺功能和支气管反应性（n=3728-3784）。
68%的母亲有足够（>50nmol/L）的 25（OH）D 浓度，27%的母亲浓度不足（27.5-49.99nmol/L），5%的母亲浓度不足（<27.5nmol/L）。没有证据表明孕妇怀孕期间的 25（OH）D 浓度与后代的任何呼吸道或过敏结果有关。这些发现在校正了测量季节和潜在混杂因素后仍然存在。也没有证据表明这些关系呈非线性形式，也没有证据表明母体 25（OH）D 浓度不足或过高与过敏或呼吸道结果有关。
我们没有发现证据表明孕妇怀孕期间的血液 25（OH）D 浓度与儿童期过敏或呼吸道结果有关。
